Lymphocyte function in patients with recurrent aphthous ulcers.

Lymphocyte proliferation (LP) responses to mitogens: phytohemagglutinin (PHA), concanavalin A (ConA) and pokeweed mitogens (PWM) were studied in 17 patients with recurrent aphthous ulcers (RAU) of minor type (MiAU) and 20 age/sex-matched healthy subjects. RAU patients elicited normal T-cell and B-cell responses to mitogens in comparison with healthy subjects. Proliferative responses were neither enhanced during active episodes of oral ulceration nor suppressed during periods of remission. It seems unlikely that non-specific lymphocyte dysfunction plays a major role in the pathogenesis of RAU.