Loevinsohn Gideon, Hardick Justin, Mehoke Thomas, Sinywimaanzi Pamela, Hamahuwa Mutinta, Fenstermacher Katherine Z J, Shaw-Saliba Kathryn, Thielen Peter, Evans Jared, Bowden Kenneth, Zudock Kristina, Sauer Lauren M, Monze Mwaka, Gaydos Charlotte A, Rothman Richard E, Pekosz Andrew, Thuma Philip E, Sutcliffe Catherine G
1Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
2Johns Hopkins School of Medicine, Baltimore, Maryland.
Am J Trop Med Hyg. 2021 Jul 19;105(3):818-821. doi: 10.4269/ajtmh.20-1470.
The burden of nosocomial respiratory infections in rural southern Africa is poorly understood. We established a surveillance program at a rural Zambian hospital to detect influenza-like illness (ILI) and respiratory infections among hospitalized patients and a cohort of healthcare workers (HCWs). Nasopharyngeal specimens from symptomatic patients and HCWs underwent broadly multiplexed molecular testing to detect viruses and atypical bacteria. During 1 year of surveillance, 15 patients (1.7% of admissions) developed ILI more than 48 hours after admission. Among 44 HCWs, 19 (43%) experienced at least one ILI episode, with a total of 31 ILI episodes detected. Respiratory viruses were detected in 45% of patient and 55% of HCW specimens. The cumulative incidence of influenza infection among HCWs over 1 year was 9%. Overall, respiratory viruses were commonly found among patients and HCWs in a rural Zambian hospital with limited infection control infrastructure.
非洲南部农村地区医院获得性呼吸道感染的负担目前了解甚少。我们在赞比亚一家农村医院建立了一个监测项目，以检测住院患者及一组医护人员中的流感样疾病（ILI）和呼吸道感染情况。有症状的患者及医护人员的鼻咽拭子标本接受了广泛的多重分子检测，以检测病毒和非典型细菌。在为期1年的监测期间，15名患者（占入院人数的1.7%）在入院48小时后出现ILI。在44名医护人员中，19人（43%）至少经历过一次ILI发作，共检测到31次ILI发作。45%的患者标本和55%的医护人员标本中检测到呼吸道病毒。1年期间医护人员中流感感染的累积发病率为9%。总体而言，在赞比亚一家农村医院，感染控制基础设施有限，患者和医护人员中普遍发现呼吸道病毒。
