Nigam Jitendra S, Kumar Tarun, Bharti Shreekant, Sinha Ruchi, Bhadani Punam P
Pathology/Lab Medicine, All India Institute of Medical Sciences, Patna, IND.
Cureus. 2021 Jun 13;13(6):e15621. doi: 10.7759/cureus.15621. eCollection 2021 Jun.
Background Carcinoma of the breast is one of the most common cancer in females, with preponderance among urban females. The patient's age, tumor size, lymph node status, histological type, histological grade, lymphovascular invasion, hormonal receptor status, human epidermal growth factor receptor 2 (Her2neu) expression, and Ki-67 labeling index for proliferation rate can help determine the appropriate management strategy in these patients. The authors conducted this descriptive retrospective study to assess the association of Ki-67 with clinicopathological parameters in a newly established institute. This may help guide treatment planning in developing countries. Methodology Patients diagnosed with primary breast cancer in our institute between January 2017 and March 2020 were included in this study. The clinicopathological prognostic factors were retrieved from the records. Results A total of 129 cases of core needle biopsy and mastectomy specimens were included in this study. The patient's mean age and median age were 47.41 and 47 years, respectively. Only 56 specimens of mastectomy were received. T2 (26/56) was the most common tumor size. Grading was done in 46 cases, and grade 2 (23/46) was the most common. Estrogen, progesterone, and Her2neu were positive in 65, 61, and 59 cases, respectively. Only estrogen receptor (ER) expression (p = 0.035) and Her2neu (p = 0.035) overexpression were significantly correlated with Ki-67. Conclusions Ki-67 expression was correlated with clinicopathological factors. Only ER expression and Her2neu overexpression were significantly associated with Ki-67. Hence, patients with high Ki-67 expression may have better responses to hormonal therapy and chemotherapy.
背景 乳腺癌是女性最常见的癌症之一，在城市女性中更为普遍。患者的年龄、肿瘤大小、淋巴结状态、组织学类型、组织学分级、淋巴管浸润、激素受体状态、人表皮生长因子受体2（Her2neu）表达以及增殖率的Ki-67标记指数有助于确定这些患者的适当管理策略。作者进行了这项描述性回顾性研究，以评估一家新成立机构中Ki-67与临床病理参数的关联。这可能有助于指导发展中国家的治疗计划。方法 本研究纳入了2017年1月至2020年3月期间在我院诊断为原发性乳腺癌的患者。从记录中检索临床病理预后因素。结果 本研究共纳入129例粗针活检和乳房切除术标本。患者的平均年龄和中位年龄分别为47.41岁和47岁。仅收到56例乳房切除术标本。T2（26/56）是最常见的肿瘤大小。对46例进行了分级，2级（23/46）是最常见的。雌激素、孕激素和Her2neu分别在65例、61例和59例中呈阳性。仅雌激素受体（ER）表达（p = 0.035）和Her2neu（p = 0.035）过表达与Ki-67显著相关。结论 Ki-67表达与临床病理因素相关。仅ER表达和Her2neu过表达与Ki-67显著相关。因此，Ki-67高表达的患者可能对激素治疗和化疗有更好的反应。
