亨廷顿病患者与其子女间交流的神经生物学和心理社会相关性研究。
Neurobiological and Psychosocial Correlates of Communication Between Huntington's Disease Patients and Their Offspring.
机构信息
Department of Psychology and Human Development, Vanderbilt University, Nashville, Tenn. (Watson, Ciriegio, Jones, Grice, Compas); and Department of Neurology, Vanderbilt University Medical Center, Nashville, Tenn. (Pfalzer, Hale, Brown, Moroz, McDonell, Claassen).
出版信息
J Neuropsychiatry Clin Neurosci. 2021 Fall;33(4):321-327. doi: 10.1176/appi.neuropsych.20120309. Epub 2021 Jul 19.
OBJECTIVE
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that presents significant challenges to family communication. The investigators examined observations of communication between parents with HD and their offspring talking about the challenges of HD and explored potential correlates of their communication.
METHODS
The sample included parents with HD and their adolescent and young-adult offspring (N=64). Parent communication and chorea were independently coded from video recordings. Parents and offspring completed working memory assessments and self-reports of neuropsychiatric symptoms, stress, and coping.
RESULTS
Evidence was found for the association of observed parent-offspring communication with disease markers, psychosocial characteristics, and neurocognitive function. For parents, disease markers and working memory were correlates of communication, whereas offspring's psychiatric symptoms, stress, and coping were associated with their communication.
CONCLUSIONS
These findings have potential implications for clinical interventions to enhance communication and quality of life for HD families.
目的
亨廷顿病（HD）是一种常染色体显性神经退行性疾病，给家庭沟通带来了重大挑战。研究者们观察了 HD 患者父母与子女就 HD 挑战进行沟通的情况，并探讨了其沟通的潜在相关性。
方法
该样本包括 HD 患者父母及其青少年和青年子女（N=64）。研究者们从视频记录中独立编码了父母沟通和舞蹈病的情况。父母和子女均完成了工作记忆评估以及神经精神症状、压力和应对方式的自评。
结果
观察到的父母与子女的沟通与疾病标志物、心理社会特征和神经认知功能之间存在关联的证据。对于父母来说，疾病标志物和工作记忆与沟通相关，而子女的精神症状、压力和应对方式与他们的沟通有关。
结论
这些发现对改善 HD 家庭沟通和生活质量的临床干预具有潜在意义。
Zotero 插件