Stuyt George, Godenzini Luca, Palmer Lucy M
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Neuroscience. 2022 May 1;489:176-184. doi: 10.1016/j.neuroscience.2021.07.008. Epub 2021 Jul 17.
There has been increasing interest in the measurement and comparison of activity across compartments of the pyramidal neuron. Dendritic activity can occur both locally, on a single dendritic segment, or globally, involving multiple compartments of the single neuron. Little is known about how these dendritic dynamics shape and contribute to information processing and behavior. Although it has been difficult to characterize local and global activity in vivo due to the technical challenge of simultaneously recording from the entire dendritic arbor and soma, the rise of calcium imaging has driven the increased feasibility and interest of these experiments. However, the distinction between local and global activity made by calcium imaging requires careful consideration. In this review we describe local and global activity, discuss the difficulties and caveats of this distinction, and present the evidence of local and global activity in information processing and behavior.
人们对锥体细胞各部分活动的测量和比较越来越感兴趣。树突活动既可以在局部，即在单个树突段上发生，也可以在全局，即涉及单个神经元的多个部分时发生。关于这些树突动态如何塑造并促进信息处理和行为，我们知之甚少。尽管由于要从整个树突分支和胞体同时进行记录存在技术挑战，很难在体内对局部和全局活动进行表征，但钙成像技术的兴起增加了这些实验的可行性并引发了人们的兴趣。然而，通过钙成像区分局部和全局活动需要仔细考虑。在这篇综述中，我们描述了局部和全局活动，讨论了这种区分的困难和注意事项，并展示了局部和全局活动在信息处理和行为方面的证据。
