Functional visualization and manipulation in the marmoset brain using viral vectors.

The common marmoset, a New World monkey, has a primate-specific cortex with approximately 40 Brodmann areas. Genetically encoded calcium indicator (GECI) techniques have been applied to study the functional organization of the marmoset cortex. The success of GCaMP (a green fluorescent of GECI) imaging and other advances, including optogenetic approaches, provide an interesting and exciting opportunity to study the primate brain at the molecular and cellular levels, leading to an understanding of primate neural circuits. These approaches will help advance our knowledge on cognition in primates, including humans, and therapy for human neurological and psychiatric disorders.