Yilmaz Rahmi, Yildirim Tolga, Abudalal Ayman, Erdem Yunus
Hacettepe University Faculty of Medicine Nephrology Department, Ankara, Turkey.
Hacettepe University Faculty of Medicine Nephrology Department, Ankara, Turkey.
Nefrologia (Engl Ed). 2021 Jul 16. doi: 10.1016/j.nefro.2021.01.015.
Prevalence of hypertension increases as glomerular filtration rate (GFR) declines. Renalase metabolizes catecholamines and have an important role in blood pressure (BP) regulation. The purpose of the study was to evaluate the effect of kidney transplantation on renalase levels and BP in kidney donors and recipients.
Twenty kidney transplant recipients and their donors were included in the study. Serum renalase levels and ambulatory BP values were measured in both donors and recipients before and after transplantation. Factor associated with change in renalase and BP levels were also evaluated.
In donors; mean GFR and hemoglobin levels decreased while night-time systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels and serum renalase levels increased simultaneously after nephrectomy. Day-time SBP and DBP levels did not changed and the night/day ratio of mean arterial pressure (MAP) increased significantly. In recipients, mean GFR increased, while mean serum renalase levels, creatinine and BP levels decreased after transplantation. Correlation analysis revealed that changes in MAP correlated with alteration in serum renalase levels and GFR.
After transplantation, serum renalase levels increased in donors and decreased in recipients. The renalase levels are associated with change in MAP and circadian rhythm of BP in donors and recipients.
高血压患病率随肾小球滤过率（GFR）下降而升高。肾酶可代谢儿茶酚胺，在血压（BP）调节中起重要作用。本研究旨在评估肾移植对肾供体和受体肾酶水平及血压的影响。
本研究纳入了20名肾移植受者及其供体。在移植前后分别测量供体和受体的血清肾酶水平及动态血压值。还评估了与肾酶和血压水平变化相关的因素。
在供体中，肾切除术后平均GFR和血红蛋白水平下降，而夜间收缩压（SBP）、舒张压（DBP）水平及血清肾酶水平同时升高。日间SBP和DBP水平未改变，平均动脉压（MAP）的昼夜比值显著升高。在受体中，移植后平均GFR升高，而平均血清肾酶水平、肌酐和血压水平下降。相关性分析显示，MAP的变化与血清肾酶水平和GFR的改变相关。
移植后，供体血清肾酶水平升高，受体血清肾酶水平降低。肾酶水平与供体和受体的MAP变化及血压昼夜节律相关。
