APHP, Hôpital Saint Antoine, Service d'Hématologie Clinique et de Thérapie cellulaire, 75012, Paris, France.
Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), 75012, Paris, France.
Mucosal Immunol. 2021 Sep;14(5):1127-1132. doi: 10.1038/s41385-021-00429-z. Epub 2021 Jul 19.
Patients receiving allogeneic hematopoietic cell transplantation (alloHCT) were previously shown to display a bacterial gut dysbiosis; however, limited data are available regarding the role of fungal microbiota in these patients. We evaluated the bacterial and fungal composition of the fecal microbiota at day 0 of alloHCT. Higher bacterial diversity was associated with an improved overall survival (OS) and disease-free survival (DFS). While fungal diversity had no impact on patient outcomes, we observed that high versus low relative abundance of Candida albicans in alloHCT patients at day 0 was associated with a significantly lower OS, DFS and graft-versus-host-free, relapse-free survival (GRFS) (p = 0.0008, p = 0.0064 and p = 0.026, respectively). While these results are limited by low patient numbers and low fungal read counts in some samples, they suggest a potentially important role for C albicans in alloHCT.
先前的研究表明，接受异基因造血细胞移植（alloHCT）的患者会出现肠道细菌失调；然而，关于这些患者中真菌微生物群的作用，可用的数据有限。我们评估了 alloHCT 当天粪便微生物群的细菌和真菌组成。较高的细菌多样性与改善的总生存率（OS）和无病生存率（DFS）相关。虽然真菌多样性对患者结局没有影响，但我们观察到，alloHCT 患者在第 0 天的白色念珠菌相对丰度较高与较低的 OS、DFS 和移植物抗宿主病无复发生存（GRFS）相关（p=0.0008、p=0.0064 和 p=0.026，分别）。虽然这些结果受到患者数量少和部分样本真菌读数低的限制，但它们表明白色念珠菌在 alloHCT 中可能具有重要作用。
