Department of Medicine, University of Cambridge, Cambridge, UK.
Academic Unit for Ageing and Stroke Research, University of Leeds, Leeds, UK.
Int J Stroke. 2022 Mar;17(3):251-259. doi: 10.1177/17474930211034331. Epub 2021 Aug 4.
Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings.
衰弱是一种独特的健康状态，老年人应对急性应激的能力因生理储备和多器官系统功能随年龄相关下降而导致的易感性增加而受损。尽管与年龄、多种合并症和残疾密切相关，但衰弱是一种与多种医疗状况不良结局相关的离散综合征。然而，它在脑血管疾病和中风中的作用受到的关注有限。在未来几十年，人口结构变化预计会导致衰弱的患病率上升，这使得衰弱成为中风从业者、脑血管研究、临床服务提供和中风幸存者的一个重要问题。这篇综述将考虑衰弱的概念和模型，衰弱在脑血管疾病中的常见程度，衰弱对中风危险因素、急性治疗和康复的影响，以及在脑血管临床和研究环境中的未来应用的考虑因素。
