Topuzova M P, Chaykovskaya A D, Bisaga G N, Pavlova T A, Alekseeva T M
Almazov National Medical Research Centre, St Petersburg, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(6):76-80. doi: 10.17116/jnevro202112106176.
Toxoplasmosis is a widespread parasitic disease. It is caused by an intracellular parasite Toxoplasma gondii. It can affect various tissues and organs, forming cysts and continuing to replicate within them. In people with intact immune system, tissue cysts remain in latent state throughout their whole life. However, in cases of cellular immunodeficiency the infection can be reactivated, which leads to secondary generalization of the process. People with HIV most commonly present with cerebral toxoplasmosis. Non-specific neuroimaging signs, as well as absence of pathognomonic symptoms and specific laboratory data lead to difficulties of cerebral toxoplasmosis diagnosis, particularly in the cases with a history of multiple sclerosis that has similar clinical symptoms and brain MRI data suggesting of tumefactive multiple sclerosis image. A clinical case of cerebral toxoplasmosis in a female patient with multiple sclerosis and HIV infection is described.
弓形虫病是一种广泛传播的寄生虫病。它由细胞内寄生虫刚地弓形虫引起。它可影响各种组织和器官，形成囊肿并在其中持续复制。在免疫系统健全的人中，组织囊肿在其一生中都处于潜伏状态。然而，在细胞免疫缺陷的情况下，感染可能会重新激活，从而导致病情继发全身扩散。感染艾滋病毒的人最常出现脑弓形虫病。非特异性神经影像学表现，以及缺乏特征性症状和特异性实验室数据，导致脑弓形虫病的诊断困难，尤其是在有多发性硬化病史且临床症状和脑部MRI数据提示为瘤样多发性硬化影像的病例中。本文描述了一名患有多发性硬化和艾滋病毒感染的女性患者脑弓形虫病的临床病例。
