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[神经科医生临床实践中的弓形虫病]

[Toxoplasmosis in the practice of a neurologist].

作者信息

Lashch N Y, Erina O V, Nikonova A A, Nikonov A A

机构信息

Pirogov Russian National Research Medical University, Moscow, Russia.

Kaluga Regional Clinical Hospital, Kaluga, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(3):110-115. doi: 10.17116/jnevro2023123031110.

DOI:10.17116/jnevro2023123031110
PMID:36946406
Abstract

Toxoplasmosis is a zoonotic protozoal disease characterized by a chronic course, polymorphism of clinical manifestations, predominant damage to the central nervous system, organs of vision, liver and lungs. The causative agent of the disease is the obligate intracellular parasite Toxoplasma gondii, which circulates widely in the external environment and has a large circle of intermediate hosts. Toxoplasmosis is classified by the method of infection (congenital or acquired), by pathogenesis (acute or chronic), by manifestation (latent or with the manifestation of symptoms). According to the state of the human immune system, the disease can occur without immunodeficiency, while the patient has a chronic lifelong carrier, and with immunodeficiency. People with HIV most commonly present with cerebral toxoplasmosis. The article presents a case of the development of toxoplasmosis in a patient in the absence of a burdened history.

摘要

弓形虫病是一种人畜共患的原生动物疾病,其特点是病程慢性、临床表现多样、主要损害中枢神经系统、视觉器官、肝脏和肺部。该疾病的病原体是专性细胞内寄生虫刚地弓形虫,它在外部环境中广泛传播,中间宿主范围广泛。弓形虫病根据感染方式(先天性或后天性)、发病机制(急性或慢性)、表现形式(潜伏性或有症状表现)进行分类。根据人体免疫系统状态,该疾病可在无免疫缺陷的情况下发生,患者成为慢性终身携带者,也可在有免疫缺陷的情况下发生。感染艾滋病毒的人最常出现脑弓形虫病。本文介绍了一例无病史负担患者发生弓形虫病的病例。

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1
[Toxoplasmosis in the practice of a neurologist].[神经科医生临床实践中的弓形虫病]
Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(3):110-115. doi: 10.17116/jnevro2023123031110.
2
[Difficulties of cerebral toxoplasmosis diagnosis in a patient with multiple sclerosis and HIV].[一名多发性硬化症合并艾滋病患者脑弓形虫病的诊断困难]
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Fulminant diffuse cerebral toxoplasmosis as the first manifestation of HIV infection.暴发性弥漫性脑弓形虫病作为HIV感染的首发表现。
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IgG4 specific to Toxoplasma gondii excretory/secretory antigens in serum and/or cerebrospinal fluid support the cerebral toxoplasmosis diagnosis in HIV-infected patients.血清和/或脑脊液中针对弓形虫排泄/分泌抗原的 IgG4 支持 HIV 感染患者的脑弓形虫病诊断。
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[Toxoplasma serology in HIV infected patients and suspected cerebral toxoplasmosis at the Central Hospital of Bobo-Dioulasso (Burkina Faso)].[布基纳法索博博迪乌拉索中心医院艾滋病病毒感染患者的弓形虫血清学及疑似脑弓形虫病]
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Neurotoxoplasmosis diagnosis for HIV-1 patients by real-time PCR of cerebrospinal fluid.通过脑脊液实时聚合酶链反应对HIV-1患者进行神经型弓形虫病诊断。
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Use of the serum reactivity against Toxoplasma gondii excreted-secreted antigens in cerebral toxoplasmosis diagnosis in human immunodeficiency virus-infected patients.血清对弓形虫排泄-分泌抗原的反应性在人类免疫缺陷病毒感染患者脑弓形虫病诊断中的应用。
J Med Microbiol. 2008 Jul;57(Pt 7):845-850. doi: 10.1099/jmm.0.47687-0.
8
[Congenital toxoplasmosis].[先天性弓形虫病]
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9
[Rudolf-Virchow Prize 1998. Award lecture. Toxoplasmosis: a model infection for studying systemic and intracerebral immune reactions].[1998年鲁道夫·魏尔啸奖。获奖演讲。弓形虫病:用于研究全身和脑内免疫反应的模型感染]
Verh Dtsch Ges Pathol. 1998;82:9-22.
10
Toxoplasmosis of the central nervous system: Manifestations vary with immune responses.中枢神经系统弓形虫病:临床表现随免疫反应而异。
J Neurol Sci. 2021 Jan 15;420:117223. doi: 10.1016/j.jns.2020.117223. Epub 2020 Nov 9.