启动子中的多态性（-499C/G）可能是代谢综合征的保护因素：在阿扎尔队列人群中的病例对照研究。
Polymorphism (-499C/G) in promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population.
机构信息
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Arch Endocrinol Metab. 2021 Nov 3;65(4):443-449. doi: 10.20945/2359-3997000000391. Epub 2021 Jul 16.
OBJECTIVE
Globally developing metabolic syndrome (MetS) prevalence as a major health problem can be related to multiple factors of genetic and environmental. Dimethylaminohydrolase 2 (DDAH2) is the main enzyme implicated in the cardiovascular system, which regulates the nitric oxide pathway. This study investigated the association of polymorphism -499C/G (rs805305) with the risk of MetS among the Azar-Cohort population.
METHODS
The occurrence of SNP rs805305 in the gene was tested using the PCR-RFLP method in 332 MetS cases and 294 healthy controls. Afterward, the association of the allele and genotypes with the risk of MetS and its components were examined.
RESULTS
The G allele and GC genotype were significantly associated with a reduced risk of MetS ( ≤ 0.001). Also, the dominant genetic model (GG+GC) significantly decreased the risk of MetS ( = 0.001), however, in sex subtypes MetS risk was significantly reduced in males before and in females after adjustment for age ( ≤ 0.02).
CONCLUSION
The -499C/G polymorphism of may play a protective role and reduce MetS risk among the Azar-Cohort population.
目的
代谢综合征（MetS）在全球范围内的高发率已成为主要的健康问题，这可能与遗传和环境的多种因素有关。二甲基精氨酸二甲胺水解酶 2（DDAH2）是心血管系统中主要的酶，它调节一氧化氮途径。本研究调查了单核苷酸多态性-499C/G（rs805305）与阿扎尔队列人群代谢综合征风险的关系。
方法
采用 PCR-RFLP 法检测 332 例代谢综合征病例和 294 例健康对照者中 rs805305 基因的 SNP 发生情况。然后，检测等位基因和基因型与代谢综合征及其各组分风险的相关性。
结果
G 等位基因和 GC 基因型与代谢综合征风险降低显著相关（≤0.001）。此外，显性遗传模型（GG+GC）也显著降低了代谢综合征的风险（=0.001），然而，在性别亚组中，调整年龄后，男性的代谢综合征风险显著降低（≤0.02），女性则升高。
结论
可能在阿扎尔队列人群中，-499C/G 多态性与保护作用有关，可降低代谢综合征的风险。
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