Karim A K, Jacob T J, Thompson G M
Department of Pharmacology, St George's Hospital Medical School, London, U.K.
Exp Eye Res. 1987 Dec;45(6):865-74. doi: 10.1016/s0014-4835(87)80102-1.
The morphology, cell density and mitotic index of human lens epithelial cells were determined according to the region of the opacity as follows: (1) nuclear; (2) posterior subcapsular; (3) cortical; (4) nuclear and posterior subcapsular; (5) cortical and posterior subcapsular. Epithelial abnormalities, consisting of enlarged, polymorphous cells and intercellular clefts, were found in cataractous lenses involving posterior subcapsular and/or cortical opacities. In contrast to the normal pattern of cell density, the cell density of cataractous epithelia in these categories decreased from the central to the peripheral epithelium. This decrease in cell density was due to the presence of swollen cells and intercellular clefts. The central and pre-equatorial mitotic index of cataractous lens epithelia was not significantly different (range 0.002-0.008%) and no correlation was found between cataract type and mitotic index (no information was available for the equatorial region). The low mitotic index observed reflects the mature age range of cataractous lenses and in one normal lens epithelium from a 23-yr-old donor, a higher value of 0.015% was found. The relevance of these epithelial abnormalities to the normal function of the epithelium is discussed.
根据混浊区域，对人晶状体上皮细胞的形态、细胞密度和有丝分裂指数进行了如下测定：(1)核性；(2)后囊下；(3)皮质性；(4)核性和后囊下；(5)皮质性和后囊下。在涉及后囊下和/或皮质混浊的白内障晶状体中发现了上皮异常，包括细胞肿大、形态多样以及细胞间裂隙。与正常细胞密度模式相反，这些类型白内障上皮细胞的密度从中央向周边上皮细胞递减。细胞密度的降低是由于细胞肿胀和细胞间裂隙的存在。白内障晶状体上皮细胞的中央和赤道前有丝分裂指数无显著差异(范围为0.002 - 0.008%)，且未发现白内障类型与有丝分裂指数之间存在相关性(赤道区域无相关信息)。观察到的低有丝分裂指数反映了白内障晶状体的成熟年龄范围，在一位23岁供体的一个正常晶状体上皮细胞中，发现有丝分裂指数较高，为0.015%。本文讨论了这些上皮异常与上皮正常功能的相关性。
