[Relation of lymph and microcirculation dynamics in the extremities of cats as affected by bradykinin and histamine].

In perfused with constant flow isolated cat hindlimbs, i.a. infusion of 0.1-1.0 micrograms.min-1.kg-1 histamine and bradykinin caused a dilatation of arteries and veins and an increase of the capillary filtration coefficient. Histamine elevated capillary hydrostatic pressure and dilated lymphatic ducts with no alteration in the lymph formation process in the hindlimb. Bradykinin decreased capillary hydrostatic pressure and activated formation of lymph. The elevation of transcapillary fluid movement under the effect of bradykinin seems to be the result of a disturbance in colloid osmotic (oncotic) pressures on both sides of the capillary wall.