Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan, South Korea.
Department of Food Science and Technology, Pukyong National University, Busan, South Korea.
Biofouling. 2021 Jul;37(6):626-655. doi: 10.1080/08927014.2021.1948538. Epub 2021 Jul 20.
undergoes a morphological yeast-to-hyphal transition during infection, which plays a significant role in its pathogenesis. The filamentous morphology of the hyphal form has been identified as a virulence factor as it facilitates surface adherence, intertwining with biofilm, invasion, and damage to host tissues and organs. Hence, inhibition of filamentation in addition to biofilm formation is considered a viable strategy against infections. Furthermore, a good understanding of the signaling pathways involved in response to environmental cues driving hyphal growth is also critical to an understanding of pathogenicity and to develop novel therapies. In this review, first the clinical significance and transcriptional control of hyphal morphogenesis are addressed. Then, various strategies employed to suppress filamentation, prevent biofilm formation, and reduce virulence are discussed. These strategies include the inhibition of filament formation using natural or synthetic compounds, and their combination with other agents or nanoformulations.
在感染过程中，经历形态的酵母到菌丝的转变，这在其发病机制中起着重要作用。菌丝形式的丝状形态已被确定为一种毒力因子，因为它促进表面附着、与生物膜交织、侵袭和宿主组织和器官的损伤。因此，除了抑制生物膜形成之外，抑制菌丝形成也被认为是对抗感染的一种可行策略。此外，深入了解参与对环境线索反应的信号通路，这些线索驱动菌丝生长，对于理解致病性和开发新疗法也至关重要。在这篇综述中，首先讨论了菌丝形态发生的临床意义和转录控制。然后，讨论了各种用于抑制菌丝形成、防止生物膜形成和降低毒力的策略。这些策略包括使用天然或合成化合物抑制菌丝形成，以及将其与其他试剂或纳米制剂结合使用。
