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经蝶窦腺瘤切除术后，N-氨和C-蛋氨酸联合用于鉴别残留/复发性垂体腺瘤与垂体残余组织。

The combination of N-ammonia and C-methionine in differentiation of residual/recurrent pituitary adenoma from the pituitary gland remnant after trans-sphenoidal Adenomectomy.

作者信息

Zhang Fangling, He Qiao, Luo Ganhua, Long Yali, Li Ruocheng, Ding Lei, Zhang Xiangsong

机构信息

Department of Radiology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, 56#, Cemetery west Road, Guangzhou, Guangdong Province, 510055, People's Republic of China.

Department of Medical Imaging, The First Affiliated Hospital, Sun Yat-sen University, 58#, Zhongshan Er Road, Guangzhou, Guangdong Province, 510080, People's Republic of China.

出版信息

BMC Cancer. 2021 Jul 20;21(1):837. doi: 10.1186/s12885-021-08574-1.

DOI:10.1186/s12885-021-08574-1
PMID:34284745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8290571/
Abstract

BACKGROUND

This study aimed to assess the clinical usefulness of N-ammonia and C- Methionine (MET) positron emission tomography (PET)/ computed tomography (CT) in the differentiation of residual/recurrent pituitary adenoma (RPA) from the pituitary gland remnant (PGR) after trans-sphenoidal adenomectomy.

METHODS

Between June 2012 and December 2019, a total of 19 patients with a history of trans-sphenoidal adenomectomy before PET/CT scans and histological confirmation of RPA after additional surgery in our hospital were enrolled in this study. Images were interpreted by visual evaluation and semi-quantitative analysis. In semi-quantitative analysis, the maximum standard uptake value (SUVmax) of the target and gray matter was measured and the target uptake/gray matter uptake (T/G) ratio was calculated.

RESULTS

The T/G ratios of N-ammonia were significantly higher in PGR than RPA (1.58 ± 0.69 vs 0.63 ± 1.37, P < 0.001), whereas the T/G ratios of C-MET were obviously lower in PGR than RPA (0.78 ± 0.35 vs 2.17 ± 0.54, P < 0.001). Using the canonical discriminant analysis, we calculated the predicted accuracy of RPA (100%), PGR (92.9%), and the overall predicted accuracy (96.43%).

CONCLUSIONS

The combination of N-ammonia and C-MET PET/CT is valuable in the differentiation of RPA from PGR after trans-sphenoidal adenomectomy.

摘要

背景

本研究旨在评估N-氨和C-蛋氨酸（MET）正电子发射断层扫描（PET）/计算机断层扫描（CT）在经蝶窦腺瘤切除术后鉴别残留/复发性垂体腺瘤（RPA）与垂体腺残余（PGR）中的临床实用性。

方法

2012年6月至2019年12月，本研究纳入了19例在PET/CT扫描前有经蝶窦腺瘤切除术史且在我院再次手术后经组织学证实为RPA的患者。通过视觉评估和半定量分析对图像进行解读。在半定量分析中，测量目标和灰质的最大标准摄取值（SUVmax），并计算目标摄取/灰质摄取（T/G）比值。

结果

PGR中N-氨的T/G比值显著高于RPA（1.58±0.69 vs 0.63±1.37，P<0.001），而PGR中C-MET的T/G比值明显低于RPA（0.78±0.35 vs 2.17±0.54，P<0.001）。使用典型判别分析，我们计算出RPA的预测准确率为100%，PGR为92.9%，总体预测准确率为96.43%。

结论

N-氨和C-MET PET/CT联合应用在经蝶窦腺瘤切除术后鉴别RPA与PGR方面具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/72862fea1700/12885_2021_8574_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/ae2ab3f81ed4/12885_2021_8574_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/b44da7be3a33/12885_2021_8574_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/0f281d8bd444/12885_2021_8574_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/72862fea1700/12885_2021_8574_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/ae2ab3f81ed4/12885_2021_8574_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/b44da7be3a33/12885_2021_8574_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/0f281d8bd444/12885_2021_8574_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b75e/8290571/72862fea1700/12885_2021_8574_Fig4_HTML.jpg

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2
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3
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Neurosurg Rev. 2023 Jul 1;46(1):160. doi: 10.1007/s10143-023-02077-2.
Acad Radiol. 2019 Sep;26(9):1222-1228. doi: 10.1016/j.acra.2018.09.015. Epub 2018 Oct 12.
4
Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI.通过与MRI联合注册的11C-蛋氨酸PET定位后，成功治疗持续性肢端肥大症中的残留垂体腺瘤。
Eur J Endocrinol. 2016 Nov;175(5):485-498. doi: 10.1530/EJE-16-0639. Epub 2016 Aug 25.
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