Department of the Medical Imaging, The First Affiliated Hospital, Sun Yat-sen University, 58# Zhongshan Er Road, Guangzhou, Guangdong Province, 510080, People's Republic of China.
Department of Radiology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, 56#, Cemetery west Road, Guangzhou, Guangdong Province, 510055, People's Republic of China.
BMC Cancer. 2020 Jun 17;20(1):564. doi: 10.1186/s12885-020-06852-y.
Differentiation of suprasellar meningiomas (SSMs) from non-functioning pituitary macroadenomas (NFPMAs) is useful for clinical management. We investigated the utility of N-ammonia combined with F-FDG positron emission tomography (PET)/computed tomography (CT) in distinguishing SSMs from NFPMAs retrospectively.
Fourteen NFPMA patients and eleven SSM patients with histopathologic diagnosis were included in this study. Every patient underwent both F-FDG and N-ammonia PET/CT scans. The tumor to gray matter (T/G) ratios were calculated for the evaluation of tumor uptake.
The uptake of F-FDG was higher in NFPMAs than SSMs, whereas the uptake of N-ammonia was obviously lower in NFPMAs than SSMs. The differences of F-FDG and N-ammonia uptake between the two groups were significant respectively (0.92[0.46] vs 0.59[0.29], P < 0.05, F-FDG; 1.58 ± 0.56 vs 2.80 ± 1.45, P < 0.05, N-ammonia). Tumor classification demonstrated a high overall accuracy of 96.0% for differential diagnosis. When the two traces were combined, only 1 SSM was misclassified into the NFPMA group.
SSMs and NFPMAs have different metabolic characteristics on F-FDG and N-ammonia PET images. The combination of these two tracers can effectively distinguish SSMs from NFPMAs.
鞍上脑膜瘤（SSMs）与无功能垂体大腺瘤（NFPMAs）的鉴别对临床管理很有用。我们回顾性研究了 N-氨合 F-FDG 正电子发射断层扫描（PET）/计算机断层扫描（CT）在鉴别 SSMs 与 NFPMAs 中的作用。
本研究纳入了 14 例 NFPA 患者和 11 例经组织病理学诊断为 SSM 的患者。每位患者均行 F-FDG 和 N-氨合 PET/CT 扫描。计算肿瘤与灰质（T/G）比值以评估肿瘤摄取。
NFPMAs 的 F-FDG 摄取高于 SSMs，而 NFPMAs 的 N-氨摄取明显低于 SSMs。两组间 F-FDG 和 N-氨摄取的差异均有统计学意义（0.92[0.46]比 0.59[0.29]，P<0.05，F-FDG；1.58 ± 0.56 比 2.80 ± 1.45，P<0.05，N-氨）。肿瘤分类对鉴别诊断的总体准确率为 96.0%。当两种示踪剂结合时，仅有 1 例 SSM 被错误分类为 NFPA 组。
SSMs 和 NFPMAs 在 F-FDG 和 N-氨 PET 图像上具有不同的代谢特征。两种示踪剂的结合可有效鉴别 SSMs 与 NFPMAs。
