State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou 510317, China.
Yi Chuan. 2021 Jul 20;43(7):642-653. doi: 10.16288/j.yczz.20-421.
As a serine/threonine kinase, NIMA-related kinases (NEKs) play important roles in the regulation of cell cycle, and involve in several cellular activities such as centrosome separation, spindle assembly, chromatin condensation, nuclear envelope breakdown, spindle assembly checkpoint signaling, cytokinesis, cilia formation and DNA damage response. In this review, we summarize the component, structural characteristics and functions of NEK family in mitosis and meiosis based on the relevant researches in recent years, providing a reference for the further study on the roles of NEKs in the regulation of cell cycle and a theoretical basis for the clinical diagnosis and treatment of tumors.
作为丝氨酸/苏氨酸激酶，丝氨酸苏氨酸激酶（NIMA）相关激酶（NEKs）在细胞周期调控中发挥重要作用，并参与中心体分离、纺锤体组装、染色质浓缩、核膜破裂、纺锤体组装检查点信号转导、胞质分裂、纤毛形成和 DNA 损伤反应等多种细胞活动。本文综述了近年来相关研究中 NEK 家族在有丝分裂和减数分裂中的组成、结构特征和功能，为进一步研究 NEKs 在细胞周期调控中的作用提供参考，为肿瘤的临床诊断和治疗提供理论依据。
