与无症状 SARS-CoV-2 感染相关的严重获得性血友病。
Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection.
机构信息
Department of Internal Medicine, NSLIJ Health System, New Hyde Park, New York, USA
Department of Internal Medicine, NSLIJ Health System, New Hyde Park, New York, USA.
出版信息
BMJ Case Rep. 2021 Jul 20;14(7):e242884. doi: 10.1136/bcr-2021-242884.
Abstract
A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports.
摘要
一位 65 岁男性出现手臂严重皮下出血症状，导致需要筋膜切开术和大量输血协议的筋膜间室综合征。既往有自身免疫性甲状腺疾病病史。检查结果显示部分凝血活酶时间升高，VIII 因子水平降低，VIII 因子抑制物水平升高。他因获得性血友病 A 进行了检查，并发现 SARS-CoV-2 抗体水平升高。鉴于他对其他继发性病因的检查结果为阴性，我们怀疑他的血友病 A 是由 SARS-CoV-2 感染引起的，先前在各种病例报告中已有观察到这种情况。
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