Ko Young Jun
Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Yongin, Korea.
J Exerc Rehabil. 2021 Jun 30;17(3):153-157. doi: 10.12965/jer.2142300.150. eCollection 2021 Jun.
Obesity causes atrophy of the brain, leading to deterioration in working memory, learning, and cognitive function. The status of short-term memory in rat pups born to older obese mother rats was verified, and the effect of treadmill exercise on short-term memory in rat pups was investigated. Step-down avoidance test for short-term memory, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining for apoptosis, and immunohistochemistry for Ki67 for new cell generation were done. The old female rats were fed with normal diet (5% of fat), and the old and obese female rats were fed with high-fat diet (60% of fat) for up to 50 weeks in age (for 44 weeks in experimental period). The newborn rats were divided into four groups according to the conditions of the mother rats as follows: the rat pups group born to old rats, the rat pups group born to old rats with exercise, the rat pups group born to old and obese rats, the rat pups group born to old and obese rats with exercise. Maternal exercise improved short-term memory, decreased TUNEL-positive cell number, and increased Ki67-positive cell number of the pups born to old and obese rats. Maternal exercise has been found to contribute to eliminating the health risks of fetuses born to old obese mothers.
肥胖会导致大脑萎缩，进而致使工作记忆、学习和认知功能衰退。对老年肥胖母鼠所生幼鼠的短期记忆状况进行了验证，并研究了跑步机运动对幼鼠短期记忆的影响。进行了用于短期记忆的避暗试验、用于细胞凋亡的末端脱氧核苷酸转移酶介导的dUTP缺口末端标记（TUNEL）染色以及用于新细胞生成的Ki67免疫组织化学检测。老年雌性大鼠喂食正常饮食（脂肪含量5%），老年肥胖雌性大鼠喂食高脂饮食（脂肪含量60%），直至50周龄（实验期44周）。新生大鼠根据母鼠情况分为四组：老年大鼠所生幼鼠组、老年大鼠运动后所生幼鼠组、老年肥胖大鼠所生幼鼠组、老年肥胖大鼠运动后所生幼鼠组。母体运动改善了老年肥胖大鼠所生幼鼠的短期记忆，减少了TUNEL阳性细胞数量，并增加了Ki67阳性细胞数量。已发现母体运动有助于消除老年肥胖母亲所生胎儿的健康风险。
