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免疫功能正常患者的播散性诺卡菌病。

Disseminated nocardiosis in an immunocompetent patient.

作者信息

Ndlovu M, Jeena P M, Thula S A, Singh S A, Masekela R

机构信息

Department of Paediatrics and Child Health, Nelson R Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.

出版信息

Afr J Thorac Crit Care Med. 2019 Dec 6;25(4). doi: 10.7196/AJTCCM.2019.v25i4.026. eCollection 2019.

Abstract

Nocardiosis is a rare opportunistic bacterial infection. We describe an 8-year-old immunocompetent patient who presented with constitutional symptoms suggestive of probable tuberculosis (TB) in whom we confirmed a diagnosis of nocardiosis. is a Gram-positive bacterium that is ubiquitous in soil and decaying vegetable matter. is the most common species. Despite the traditional description of nocardiosis as an opportunistic infection, case reports and case series of pulmonary nocardiosis have recently been reported in immunocompetent patients. Three clinical presentations of nocardiosis have been described; acute, subacute and chronic suppurative infections with episodes of exacerbations and remissions. We describe the presentation, diagnosis, management and prognosis of a rare case of disseminated nocardiosis managed initially as disseminated TB with no improvement.

摘要

诺卡菌病是一种罕见的机会性细菌感染。我们描述了一名8岁免疫功能正常的患者,该患者出现提示可能为结核病(TB)的全身症状,我们确诊其患有诺卡菌病。诺卡菌是一种革兰氏阳性菌,在土壤和腐烂的植物中普遍存在。星形诺卡菌是最常见的菌种。尽管传统上将诺卡菌病描述为机会性感染,但最近有免疫功能正常患者发生肺诺卡菌病的病例报告和病例系列。诺卡菌病有三种临床表现;急性、亚急性和慢性化脓性感染,伴有病情加重和缓解期。我们描述了一例罕见的播散性诺卡菌病的表现、诊断、治疗及预后,该病例最初被当作播散性结核病治疗但无改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92da/8278857/e96f18a71081/AJTCCM-25-4-026-fig1.jpg

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