Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.
Chem Soc Rev. 2021 Sep 7;50(17):9766-9793. doi: 10.1039/d0cs01124j. Epub 2021 Jul 21.
The past two decades have witnessed remarkable growth of asymmetric organocatalysis, which is now a firmly established synthetic tool, serving as a powerful platform for the production of chiral molecules. Ring structures are ubiquitous in organic compounds, and, in the context of natural product synthesis, strategic construction of ring motifs is often crucial, fundamentally impacting the eventual fate of the whole synthetic plan. In this review, we provide a comprehensive and updated summary of asymmetric organocatalytic annulation reactions; in particular, the application of these annulation strategies in natural product synthesis will be highlighted.
过去二十年见证了不对称有机催化的显著发展，它现在是一个稳固确立的合成工具，作为手性分子生产的强大平台。环结构在有机化合物中无处不在，在天然产物合成的背景下，环基的战略构建通常是至关重要的，从根本上影响整个合成计划的最终结果。在这篇综述中，我们提供了一个全面和更新的不对称有机催化环化反应的总结；特别是，这些环化策略在天然产物合成中的应用将被强调。
