Zhao Jiangui, Zheng Xueli, Tao Shaokun, Zhu Yuxin, Yi Jiwei, Tang Songbai, Li Ruixiang, Chen Hua, Fu Haiyan, Yuan Maolin
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China.
West China School of Medicine, Sichuan University, 17 South Renmin Road, Chengdu 610041, P. R. China.
Org Lett. 2021 Aug 6;23(15):6067-6072. doi: 10.1021/acs.orglett.1c02140. Epub 2021 Jul 21.
The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important -(poly)enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.
末端芳基炔烃和烯炔的氢甲酰化反应为合成有价值的（多）烯醛提供了一条直接的路线。然而，末端炔烃的氢甲酰化反应一直是一个长期存在的挑战。在此，通过使用一种具有强π-受体能力的新型稳定双磷酰胺配体，实现了铑催化的末端芳基炔烃和共轭烯炔的高效选择性氢甲酰化反应，该反应在低温和低合成气压力下，以良好的产率、出色的化学选择性和区域选择性得到了各种重要的（多）烯醛。
