Gosselin Robert C
Hemostasis & Thrombosis Center, Davis Health System, University of California, Sacramento, CA, USA.
Int J Lab Hematol. 2021 Jul;43 Suppl 1:109-116. doi: 10.1111/ijlh.13585.
There are many preanalytical variables (PAV) that are known to affect coagulation testing. The more commonly acknowledged PAV addressed by the clinical laboratory tend to start with their influence on blood collection, but realistically coagulation PAV starts with the patient, where the laboratory has less influence or control. Patient selection and appropriate timing for blood collection may be integral for assuring proper diagnosis and management. Laboratory control and assurance for ideal phlebotomy practice would mitigate most PAVs related to blood collection to minimize suboptimal sample collection. Laboratory oversight of sample transportation, processing and storage will assure sample integrity until testing can be facilitated. The purpose of this document is to review common PAV that should be taken into consideration when ordering, performing and interpreting a coagulation test result, with additional attention to the effect of direct oral anticoagulants (DOACs).
已知有许多分析前变量（PAV）会影响凝血检测。临床实验室更常认可的PAV往往始于它们对血液采集的影响，但实际上凝血PAV始于患者，而实验室在这方面的影响或控制较小。患者选择和合适的采血时间对于确保正确的诊断和管理可能至关重要。实验室对理想采血操作的控制和保证将减轻大多数与血液采集相关的PAV，以尽量减少次优样本采集。实验室对样本运输、处理和储存的监督将确保样本完整性，直到能够进行检测。本文档的目的是回顾在订购、进行和解释凝血检测结果时应考虑的常见PAV，并特别关注直接口服抗凝剂（DOACs）的影响。
