Baenkler H W, Lux G, Günthner R, Kohlhäufl M, Matek W
Institute of Clinical Immunology, University of Erlangen, Germany.
Hepatogastroenterology. 1987 Dec;34(6):289-90.
The histamine content of biopsy specimens obtained from patients with ulcerative colitis (UC), Crohn's disease (CD), or polyps was measured in vitro. This was done using colonic and rectal mucosa taken from affected and healthy tissue. In general, the results demonstrate a significantly higher histamine content in patients with UC. This was true with respect to colonic as well as rectal mucosa. Moreover, affected mucosa contained significantly more histamine than normal in UC and in CD. The histamine content of colonic and rectal mucosa was similar within each patient group. However, specimens from patients with UC again contained significantly more histamine than did those of patients with CD. The data underscore a distinct pathomechanism in UC and in CD. Therefore, determination of the histamine content of biopsy specimens may be an adjuvant criterion for the discrimination of different inflammatory bowel diseases.
对溃疡性结肠炎（UC）、克罗恩病（CD）或息肉患者的活检标本中的组胺含量进行了体外测量。这是通过取自患病组织和健康组织的结肠及直肠黏膜来完成的。总体而言，结果表明UC患者的组胺含量显著更高。结肠及直肠黏膜均是如此。此外，在UC和CD中，患病黏膜中的组胺含量明显高于正常黏膜。每个患者组内结肠和直肠黏膜的组胺含量相似。然而，UC患者的标本中的组胺含量再次显著高于CD患者的标本。这些数据强调了UC和CD中不同的发病机制。因此，测定活检标本中的组胺含量可能是鉴别不同炎症性肠病的辅助标准。
