Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET), Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
Planta Piloto de Procesos Industriales Microbiológicos (PROIMI, CONICET), San Miguel de Tucumán, Argentina.
Crit Rev Microbiol. 2022 Feb;48(1):21-41. doi: 10.1080/1040841X.2021.1939266. Epub 2021 Jul 21.
Several strains are important nosocomial pathogens, with being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical setting. Colonisation of this environment is associated with a multitude of bacterial factors, and the molecular features that promote environmental persistence in abiotic surfaces, including intrinsic desiccation resistance, biofilm formation and motility, have been previously addressed. On the contrary, mechanisms enabling . survival when faced against other biological competitors are starting to be characterised. Among them, secretion systems (SS) of different types, such as the T5bSS (Contact-dependent inhibition systems) and the T6SS, confer adaptive advantages against bacterial aggressors. Regarding mechanisms of defence against bacteriophages, such as toxin-antitoxin, restriction-modification, Crispr-Cas and CBASS, among others, have been identified but remain poorly characterised. In view of this, we aimed to summarise the present knowledge on defence mechanisms that enable niche establishment in members of the genus. Different proposals are also described for the use of some components of these systems as molecular tools to treat infections.
有几种菌株是重要的医院病原体，其中由于其多药耐药性以及最近在临床环境中出现的高毒力菌株， 是引起全球关注的物种。这种环境的定植与多种细菌因素有关，先前已经研究了促进在非生物表面环境中持久存在的分子特征，包括固有干燥抗性、生物膜形成和运动性。相反，当面临其他生物竞争者时，使 得以生存的机制开始被描述。其中，不同类型的分泌系统（SS），如 T5bSS（接触抑制系统）和 T6SS，赋予了针对细菌侵袭者的适应性优势。至于防御噬菌体的机制，如毒素-抗毒素、限制修饰、CRISPR-Cas 和 CBASS 等，已经被识别出来，但仍未得到很好的描述。有鉴于此，我们旨在总结使 属成员在特定生态位中建立的防御机制的现有知识。还描述了一些提议，以将这些系统的某些成分用作治疗 感染的分子工具。
