Servicio de Microbiología, Complejo Hospitalario Universitario A Coruña (CHUAC)-Instituto de Investigación Biomédica (INIBIC), A Coruña, Spain.
Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospital Universitario Virgen Macarena, Seville, Spain.
Antimicrob Agents Chemother. 2018 Apr 26;62(5). doi: 10.1128/AAC.00250-18. Print 2018 May.
The molecular mechanisms of tolerance and persistence associated with several compounds in clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
几种临床分离株中与耐受性和持久性相关的化合物的分子机制尚不清楚。通过转录组学和表型研究，我们发现，在属于临床克隆 ST-2 的一株菌中，细菌对氯己定的耐受性机制与亚胺培南存在时的持久性之间存在关联（OXA-24 型β-内酰胺酶和 AbkAB 毒素-抗毒素 [TA] 系统位于质粒上）。有趣的是，ATCC 17978 株（来自质粒的 AbkAB TA 系统）在亚胺培南和氯己定存在的情况下表现出持久性。
