Felli Emanuele, Ishizawa Takeaki, Cherkaoui Zineb, Diana Michele, Tripon Simona, Baumert Thomas F, Schuster Catherine, Pessaux Patrick
Digestive and Endocrine Surgery, Nouvel Hôpital Civil, University of Strasbourg, Strasbourg, France; IHU Strasbourg, Institute for Image-Guided Surgery, Strasbourg, France; IRCAD, Research Institute Against Digestive Cancer, Strasbourg, France; Institute of Viral and Liver Disease, INSERM U1110, Strasbourg, France.
Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Japan; Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
HPB (Oxford). 2021 Nov;23(11):1647-1655. doi: 10.1016/j.hpb.2021.05.006. Epub 2021 Jun 7.
Indications for a minimally invasive resections are increasing worldwide, but respecting anatomical planes during intraparenchymal transection is demanding. Intraoperative ICG fluorescence staining of liver parenchyma has been introduced as a tool for real-time intraoperative guidance. The aim of this study is to make a systematic review of the current relevant literature on indications, techniques, and results of laparoscopic anatomical liver resection (LALR) using intraoperative indocyanine green (ICG) fluorescence for positive and negative staining of liver segments in patients affected by liver malignancies.
Electronic bibliographical databases (MEDLINE and PubMed) were searched according to the PRISMA criteria. English language articles meeting the selection criteria and published until June 2020 were retrieved and reviewed.
a total of 86 articles were initially found and 11 articles were finally included in the analysis with a total of 83 patients treated. Sixty-two patients (74.6%) underwent mono-segmentectomies. Thirty-five patients (42.1%) underwent the positive staining technique, and forty-eight patients (57.8%) the negative staining technique.
The positive or negative indocyanine green staining technique with real-time fluorescence guidance is an emerging and promising approach. However, the technique has to be standardized and advantages in terms of oncologic results still need validation in further studies.
在全球范围内，微创肝切除术的适应症正在增加，但在肝实质内横断时遵循解剖平面具有挑战性。术中吲哚菁绿（ICG）荧光染色已被引入作为实时术中引导的工具。本研究的目的是对当前相关文献进行系统综述，这些文献涉及使用术中吲哚菁绿（ICG）荧光对肝恶性肿瘤患者肝段进行阳性和阴性染色的腹腔镜解剖性肝切除术（LALR）的适应症、技术和结果。
根据PRISMA标准检索电子文献数据库（MEDLINE和PubMed）。检索并回顾了符合选择标准且截至2020年6月发表的英文文章。
最初共找到86篇文章，最终11篇文章纳入分析，共治疗83例患者。62例患者（74.6%）接受了单肝段切除术。35例患者（42.1%）采用阳性染色技术，48例患者（57.8%）采用阴性染色技术。
实时荧光引导下的吲哚菁绿阳性或阴性染色技术是一种新兴且有前景的方法。然而，该技术必须标准化，其在肿瘤学结果方面的优势仍需在进一步研究中得到验证。
