Associate Professor of Pediatrics, Division of Neonatology, Department of Pediatrics, Research and Training Hospital of Sakarya University, Adapazarı, Sakarya, Türkiye.
Specialist in Pediatrics, Department of Pediatrics, Research and Training Hospital of Sakarya University, Adapazarı, Sakarya, Türkiye.
Niger J Clin Pract. 2021 Jul;24(7):1061-1066. doi: 10.4103/njcp.njcp_294_20.
We aimed to determine the normal immunoglobulin values of Turkish new-borns by studying IgG, IgA, IgM, and IgG subgroups (IgG1, IgG2, IgG3, and IgG4) from term, healthy neonates born in the Sakarya province of Turkey.
In our study, IgA, IgM, IgG, and IgG subgroup levels were measured nephelometrically in 54 new-borns (15-21-day-old). They were born between 39 and 41 weeks of gestation by problem-free delivery and with Apgar scores >8 at 1 and 5 minutes. The enrolled neonates were singletons and were free of congenital diseases/anomalies, history of perinatal infection, and with no known history of transfusion or chronic disease in the mother. The study findings were also evaluated in terms of differences based on delivery mode, feeding type, gender, and demographic characteristics.
This study enrolled 54 new-borns, 42 (77.8%) of whom were born by cesarean section and 12 (22.2%) by spontaneous vaginal delivery. Of the new-borns, 41 (75.9%) were only breastfed, and 13 (24.1%) were fed with combined breast milk and baby formula. The 95% confidence intervals of serum immunoglobulins and IgG subgroups were as follows: IgG, 652-722 mg/dL; IgA, 6-8 mg/dL; IgM, 27-35 mg/dL; IgG1, 495.7-544.3 mg/dL; IgG2, 139.6-169.5 mg/dL; IgG3, 22.7-27.7 mg/dL; and IgG4, 21.5-33.7 mg/dL. There was no significant correlation between any demographic characteristic and any immunoglobulin type. A low-moderate but significant negative correlation (r: -0.34) was found between birth length and IgA and a low-moderate but significant positive correlation (r: 0.32) was found between head circumference and IgM level.
Our study provided usable data on the normal values of serum IgG, IgA, IgM, and IgG subgroups among healthy Turkish new-borns. This study is thought to be one of the most standardized and reliable reference sources for our country.
通过研究来自土耳其萨卡里亚省足月、健康新生儿的 IgG、IgA、IgM 和 IgG 亚类（IgG1、IgG2、IgG3 和 IgG4），确定土耳其新生儿的正常免疫球蛋白值。
在我们的研究中，使用 nephelometry 测量了 54 名新生儿（15-21 天大）的 IgA、IgM、IgG 和 IgG 亚类水平。他们在无问题的分娩下，妊娠 39 至 41 周，出生，在 1 分钟和 5 分钟时 Apgar 评分为>8。入组的新生儿均为单胎，无先天性疾病/畸形、围产期感染史，且母亲无已知输血或慢性病史。还根据分娩方式、喂养类型、性别和人口统计学特征评估了研究结果的差异。
本研究纳入了 54 名新生儿，其中 42 名（77.8%）经剖宫产分娩，12 名（22.2%）经自然阴道分娩。新生儿中，41 名（75.9%）仅母乳喂养，13 名（24.1%）母乳喂养和婴儿配方奶混合喂养。血清免疫球蛋白和 IgG 亚类的 95%置信区间如下：IgG，652-722mg/dL；IgA，6-8mg/dL；IgM，27-35mg/dL；IgG1，495.7-544.3mg/dL；IgG2，139.6-169.5mg/dL；IgG3，22.7-27.7mg/dL；和 IgG4，21.5-33.7mg/dL。任何人口统计学特征与任何免疫球蛋白类型之间均无显著相关性。出生长度与 IgA 呈低中度但显著负相关（r：-0.34），头围与 IgM 水平呈低中度但显著正相关（r：0.32）。
本研究为健康土耳其新生儿血清 IgG、IgA、IgM 和 IgG 亚类的正常值提供了可用数据。该研究被认为是我国最标准化和可靠的参考来源之一。
