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How the amino acid leucine activates the key cell-growth regulator mTOR.

作者信息

Vellai Tibor

出版信息

Nature. 2021 Aug;596(7871):192-194. doi: 10.1038/d41586-021-01943-7.

DOI:10.1038/d41586-021-01943-7

Abstract

摘要

相似文献

[1]

How the amino acid leucine activates the key cell-growth regulator mTOR.

Nature. 2021-8

[2]

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Cell Signal. 2014-9

[3]

Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice.

FASEB J. 2004-12

[4]

Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer.

Cell Oncol (Dordr). 2022-10

[5]

Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats.

Am J Physiol Endocrinol Metab. 2002-10

[6]

Leucine-enriched amino acids maintain peripheral mTOR-Rheb localization independent of myofibrillar protein synthesis and mTORC1 signaling postexercise.

J Appl Physiol (1985). 2020-7-1

[7]

The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes.

BMC Physiol. 2011-6-25

[8]

Lysosomal accumulation of mTOR is enhanced by rapamycin.

Histochem Cell Biol. 2010-11-10

[9]

Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.

J Nutr Biochem. 2012-8-13

[10]

IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway.

Mol Cell Endocrinol. 2015-9-5

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本文引用的文献

[1]

SAR1B senses leucine levels to regulate mTORC1 signalling.

Nature. 2021-8

[2]

SAMTOR is an -adenosylmethionine sensor for the mTORC1 pathway.

Science. 2017-11-10

[3]

mTOR Signaling in Growth, Metabolism, and Disease.

Cell. 2017-3-9

[4]

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.

Nature. 2016-8-11

[5]

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.

Cell. 2016-3-24

[6]

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Science. 2016-1-1

[7]

Sestrin2 is a leucine sensor for the mTORC1 pathway.

Science. 2016-1-1

[8]

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Science. 2013-5-31

[9]

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Nature. 2012-12-16

[10]

Genetics: influence of TOR kinase on lifespan in C. elegans.

Nature. 2003-12-11

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