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某些天然草药产品及相关化合物的毒理病理学方面

The toxicologic pathology aspects of selected natural herbal products and related compounds.

作者信息

Ibrahim Ruba, Nyska Abraham, Dunnick June, Ramot Yuval

机构信息

Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Department of Dermatology, Hadassah Medical Center, Jerusalem, Israel.

出版信息

J Toxicol Pathol. 2021 Jul;34(3):181-211. doi: 10.1293/tox.2021-0016. Epub 2021 Mar 29.

DOI:10.1293/tox.2021-0016
PMID:34290474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8280299/
Abstract

Herbal products have been in use for many years, but they are becoming more and more popular in recent years, and they are currently in widespread use throughout the world. In this review article we describe the histopathologic findings found after exposure to 12 dietary herbals in studies conducted in rodent model systems. Clear or some evidence for carcinogenic activity was seen with 6 herbals, with the liver being the most common organ affected. The intestine was affected by two herbals (aloe vera nondecolorized extract and senna), three had no clear evidence for carcinogenic activity and one was cardiotoxic (Ephedrine and Ephedra in combination with caffeine). Information from these studies can help to better understand potential target organs for further evaluation from exposure to various herbal products.

摘要

草药产品已经使用多年，但近年来它们越来越受欢迎，目前在全球广泛使用。在这篇综述文章中，我们描述了在啮齿动物模型系统中进行的研究中，暴露于12种食用草药后发现的组织病理学结果。6种草药显示出明确或一些致癌活性证据，其中肝脏是最常受影响的器官。两种草药（未脱色的芦荟提取物和番泻叶）会影响肠道，三种没有明确的致癌活性证据，一种具有心脏毒性（麻黄碱和麻黄与咖啡因联用）。这些研究的信息有助于更好地了解暴露于各种草药产品后需要进一步评估的潜在靶器官。

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