Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Halal Research Centre of IRI, FDA, Tehran, Iran; Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Diabetes Metab Syndr. 2020 Jul-Aug;14(4):293-301. doi: 10.1016/j.dsx.2020.03.018. Epub 2020 Apr 5.
Previous studies have indicated controversial results regarding the efficacy of green tea extract (GTE) in improving the lipid profile of type 2 diabetes mellitus (T2DM) patients. We aimed to conduct a systematic review and meta-analysis to pool data from randomized controlled trials (RCTs).
A systematic search was performed in Web of Science, PubMed, and Scopus databases, without any language and time restriction until August 2019, to retrieve the RCTs which examined the effects of GTE on serum concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG) or total cholesterol (TC) in T2DM patients. Meta-analyses were carried out using a random effects model. I2 index was used to evaluate the heterogeneity.
Initial search yielded 780 publications. Of these, seven studies were eligible. The supplementary intake of GTE improved lipid profile by reducing serum TG concentrations in patients with T2DM. Meanwhile, subgroup analyses based on duration of interventions (≤8 and > 8 weeks) and intervention dosage (≤800 and > 800 mg/day) showed that the GTE supplementation longer than 8 weeks and in doses >800 mg/day resulted in a significant decrease in serum TG concentrations. Furthermore, intervention longer than 8 weeks with doses lower than 800 mg/day resulted in a significant reduction in serum TC concentrations.
In conclusion, present systematic review and meta-analysis revealed that the supplementary intake of GTE may improve lipid profile by reducing serum concentrations of TG in patients with T2DM. Furthermore, the results of our stratified analyses suggested that long-term GTE intervention may reduce serum concentrations of TG and TC.
先前的研究表明，绿茶提取物（GTE）在改善 2 型糖尿病（T2DM）患者的血脂谱方面的疗效存在争议。我们旨在进行系统评价和荟萃分析，以汇总来自随机对照试验（RCT）的数据。
在 Web of Science、PubMed 和 Scopus 数据库中进行系统搜索，没有任何语言和时间限制，直到 2019 年 8 月，以检索检查 GTE 对 T2DM 患者血清高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）或总胆固醇（TC）浓度影响的 RCT。使用随机效应模型进行荟萃分析。使用 I2 指数评估异质性。
初步搜索产生了 780 篇出版物。其中，有七项研究符合条件。补充 GTE 可通过降低 T2DM 患者的血清 TG 浓度来改善血脂谱。同时，基于干预持续时间（≤8 周和>8 周）和干预剂量（≤800 毫克/天和>800 毫克/天）的亚组分析表明，GTE 补充剂的持续时间超过 8 周且剂量>800 毫克/天，导致血清 TG 浓度显著降低。此外，剂量低于 800 毫克/天且干预时间超过 8 周，可显著降低血清 TC 浓度。
总之，本系统评价和荟萃分析表明，补充 GTE 可能通过降低 T2DM 患者的血清 TG 浓度来改善血脂谱。此外，我们的分层分析结果表明，长期 GTE 干预可能降低血清 TG 和 TC 浓度。
