Salonen M, Kanto J, Iisalo E
Department of Anesthesiology, Turku University Central Hospital, Finland.
Int J Clin Pharmacol Ther Toxicol. 1987 Nov;25(11):613-5.
The pharmacodynamics of midazolam was studied in 27 children undergoing elective surgery at five different dose levels (0.075-0.6 mg/kg) in attempting to find a suitable induction dose for general anesthesia. A comparison of the highest dose was made to thiopentone 5 mg/kg. Even an induction dose of 0.6 mg/kg of midazolam was found to be unreliable in children, but effective enough to cause significant fall in systolic blood pressure after induction (p less than 0.05). In the children premedicated with atropine and pethidine thiopentone resulted in a more rapid closure of the eyes (p less than 0.01) and disappearance of the eye-lid reflex (p less than 0.01) than the high dose of 0.6 mg/kg of midazolam. Moreover, midazolam failed to induce sleep in a considerable fraction of the children even at the highest dose employed. The thiopentone group was more alert in the recovery room at 30 min after wake-up. The amnestic effect of thiopentone and midazolam were equal.
在27例接受择期手术的儿童中，研究了咪达唑仑在五个不同剂量水平（0.075 - 0.6毫克/千克）下的药效动力学，试图找到适合全身麻醉的诱导剂量。将最高剂量与硫喷妥钠5毫克/千克进行了比较。结果发现，即使是0.6毫克/千克的咪达唑仑诱导剂量在儿童中也不可靠，但足以在诱导后导致收缩压显著下降（p小于0.05）。在预先使用阿托品和哌替啶进行术前用药的儿童中，硫喷妥钠导致闭眼更快（p小于0.01），眼睑反射消失更快（p小于0.01），优于0.6毫克/千克的高剂量咪达唑仑。此外，即使在使用的最高剂量下，咪达唑仑仍未能使相当一部分儿童入睡。硫喷妥钠组在苏醒后30分钟在恢复室中更清醒。硫喷妥钠和咪达唑仑的遗忘作用相当。
