侵袭伪足中的非编码RNA：对癌症转移的新见解
Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis.
作者信息
Li Feiya, Yang Burton B
机构信息
Division of Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
出版信息
Front Oncol. 2021 Jul 5;11:681576. doi: 10.3389/fonc.2021.681576. eCollection 2021.
Invadopodia are actin-rich structures and their formation is implicated in cancer invasion and metastasis. Growing evidence has shown that noncoding RNAs (ncRNAs) play important roles in pathological conditions, including tumorigenesis and metastasis. Although this is still a new area of research, ncRNAs appear to be promising biomarkers and therapeutic targets for cancer metastasis. However, understanding the roles of ncRNAs in invadopodia is still in the early stages and far from clinical application. In this mini-review, we summarize the roles of ncRNAs in invadopodia functions and discuss them in a therapeutic context. The current challenges and gaps in this field are also raised, and we provide some open questions to facilitate new ideas in targeting invadopodia in anticancer therapy.
侵袭性伪足是富含肌动蛋白的结构，其形成与癌症侵袭和转移有关。越来越多的证据表明，非编码RNA（ncRNA）在包括肿瘤发生和转移在内的病理状况中发挥重要作用。尽管这仍是一个新的研究领域，但ncRNA似乎是癌症转移很有前景的生物标志物和治疗靶点。然而，了解ncRNA在侵袭性伪足中的作用仍处于早期阶段，离临床应用还很远。在这篇小型综述中，我们总结了ncRNA在侵袭性伪足功能中的作用，并在治疗背景下进行讨论。我们还提出了该领域当前的挑战和差距，并提供了一些开放性问题，以促进在抗癌治疗中靶向侵袭性伪足的新思路。
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