Wang Xiaolin, Chen Xiaojun, Li Guangfei, Han Xiao, Gao Tianxin, Liu Weifeng, Tang Xiaoying
School of Life Science, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing, China.
Front Oncol. 2021 Jul 5;11:708724. doi: 10.3389/fonc.2021.708724. eCollection 2021.
Carbon ion radiation therapy (CIRT) is the most advanced radiation therapy (RT) available and offers new opportunities to improve cancer treatment and research. CIRT has a unique physical and biological advantage that allow them to kill tumor cells more accurately and intensively. So far, CIRT has been used in almost all types of malignant tumors, and showed good feasibility, safety and acceptable toxicity, indicating that CIRT has a wide range of development and application prospects. In addition, in order to improve the biological effect of CIRT, scientists are also trying to investigate related sensitizing agents to enhance the killing ability of tumor cells, which has attracted extensive attention. In this review, we tried to systematically review the rationale, advantages and problems, the clinical applications and the sensitizing agents of the CIRT. At the same time, the prospects of the CIRT in were prospected. We hope that this review will help researchers interested in CIRT, sensitizing agents, and radiotherapy to understand their magic more systematically and faster, and provide data reference and support for bioanalysis, clinical medicine, radiotherapy, heavy ion therapy, and nanoparticle diagnostics.
碳离子放射治疗（CIRT）是目前最先进的放射治疗（RT）方法，为改善癌症治疗和研究提供了新机遇。CIRT具有独特的物理和生物学优势，使其能够更精确、更强烈地杀死肿瘤细胞。到目前为止，CIRT已应用于几乎所有类型的恶性肿瘤，并显示出良好的可行性、安全性和可接受的毒性，表明CIRT具有广泛的发展和应用前景。此外，为了提高CIRT的生物学效应，科学家们也在尝试研究相关的增敏剂以增强肿瘤细胞的杀伤能力，这引起了广泛关注。在本综述中，我们试图系统地综述CIRT的原理、优势与问题、临床应用以及增敏剂。同时，对CIRT的前景进行了展望。我们希望本综述能帮助对CIRT、增敏剂和放射治疗感兴趣的研究人员更系统、更快地了解它们的神奇之处，并为生物分析、临床医学、放射治疗、重离子治疗和纳米颗粒诊断提供数据参考和支持。
