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1,6-二磷酸果糖,一种代谢调节物。

Fructose-1,6-bisphosphate, a regulator of metabolism.

作者信息

Kirtley M E, McKay M

出版信息

Mol Cell Biochem. 1977 Dec 29;18(2-3):141-9. doi: 10.1007/BF00280279.

DOI:10.1007/BF00280279
PMID:342914
Abstract

Fructose-1,6-bisphosphate affects the rate of a large variety of enzyme reactions. In some instances its role as a physiologic effector is well documented. In many cases the effects of fructose bishosphate on particular enzymes have been demonstrated in vitro but the link to physiologic conditions has not yet been established. It is the purpose of this paper to summarize the scattered findings in fructose bisphosphate as an effector of enzyme reactions and to draw some conclusions about the role of the compound in metabolic regulation.

摘要

1,6 - 二磷酸果糖影响多种酶反应的速率。在某些情况下,其作为生理效应物的作用有充分的文献记载。在许多情况下,二磷酸果糖对特定酶的影响已在体外得到证实,但与生理状况的联系尚未确立。本文的目的是总结关于二磷酸果糖作为酶反应效应物的零散发现,并就该化合物在代谢调节中的作用得出一些结论。

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Fructose-1,6-bisphosphate, a regulator of metabolism.1,6-二磷酸果糖,一种代谢调节物。
Mol Cell Biochem. 1977 Dec 29;18(2-3):141-9. doi: 10.1007/BF00280279.
2
Regulation of carbohydrate metabolism by glucose 1,6-bisphosphate in extrahepatic tissues; comparison with fructose 2,6-bisphosphate.
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[Regulation of carbohydrate metabolism by fructose-2, 6-bisphosphate].[果糖-2,6-二磷酸对碳水化合物代谢的调节]
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本文引用的文献

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Studies in glycolysis: The first stages of glycolysis in muscle extracts.糖酵解研究:肌肉提取物中糖酵解的最初阶段。
Biochem J. 1938 Mar;32(3):572-84. doi: 10.1042/bj0320572.
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Inhibition of glucose phosphate isomerase by metabolic intermediates of fructose.果糖代谢中间产物对磷酸葡萄糖异构酶的抑制作用。
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Phosphofructokinase and the Pasteur effect.磷酸果糖激酶与巴斯德效应。
果糖-1,6-二磷酸逆转 L-犬尿氨酸引起的 Wistar 雄性大鼠的降压作用。
Physiol Rep. 2024 Oct;12(19):e70033. doi: 10.14814/phy2.70033.
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Metabolomics reveals high fructose-1,6-bisphosphate from fluoride-resistant Streptococcus mutans.代谢组学揭示了来自耐氟变形链球菌的1,6-二磷酸果糖。
BMC Microbiol. 2024 May 3;24(1):151. doi: 10.1186/s12866-024-03310-8.
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Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae.镉胁迫决定肺炎链球菌的中心碳通量并改变其膜组成。
Commun Biol. 2020 Nov 19;3(1):694. doi: 10.1038/s42003-020-01417-y.
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Fructose-1,6-Bisphosphate Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice and Inhibits the Proliferation of Lung Fibroblasts.果糖-1,6-二磷酸可预防博来霉素诱导的小鼠肺纤维化,并抑制肺成纤维细胞的增殖。
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Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway.1,6-二磷酸果糖是糖酵解的一种高能中间产物,它通过激活抗炎腺苷能途径减轻实验性关节炎。
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Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes.烟酰胺单核苷酸腺苷酸转移酶3(nmnat3)缺乏通过改变成熟红细胞中的糖酵解通量导致溶血性贫血。
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Fructose-1,6-bisphosphate reduces inflammatory pain-like behaviour in mice: role of adenosine acting on A1 receptors.果糖-1,6-二磷酸可减轻小鼠的炎性痛行为:腺苷通过 A1 受体发挥作用。
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ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI.大肠杆菌中的3',5'-磷酸腺苷
J Biol Chem. 1965 Mar;240:1309-14.
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FRUCTOSE-1,6-DIPHOSPHATE REQUIREMENT OF STREPTOCOCCAL LACTIC DEHYDROGENASES.链球菌乳酸脱氢酶对1,6-二磷酸果糖的需求
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2-Keto-3-deoxy-D-arabo-heptonic acid 7-phosphate synthetase.2-酮-3-脱氧-D-阿拉伯庚酮糖酸7-磷酸合成酶
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The conversion of phosphoenolpyruvic acid and D-erythrose-4-phosphate to 5-de-hydroquinic acid.磷酸烯醇丙酮酸和D-赤藓糖-4-磷酸转化为5-脱氢奎尼酸。
J Biol Chem. 1959 Apr;234(4):713-5.
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Regulation of acetyl-CoA carboxylase of Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 1967 Aug 7;28(3):415-9. doi: 10.1016/0006-291x(67)90327-0.
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Biosynthesis of bacterial glycogen. V. The activation and inhibition of the adenosine diphosphate glucose pyrophosphorylase of Arthrobacter viscosus NRRL BI973.
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Isocitrate lyase from Pseudomonas indigofera. IV. Specificity and inhibition.产靛假单胞菌异柠檬酸裂合酶。IV. 特异性与抑制作用。
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