Department of Internal Medicine, Section of Infectious Diseases and Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands.
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
Clin Infect Dis. 2022 Apr 9;74(7):1271-1274. doi: 10.1093/cid/ciab647.
Twenty-five B-cell-depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) recovered, indicating the potential therapeutic effects of this therapy in this particular population.
25 例 B 细胞耗竭患者(24 例接受抗 CD19/20 治疗)诊断为 2019 年冠状病毒病,症状中位数为 26 天,但仍为抗体阴性。所有患者均接受高中和抗体滴度的恢复期血浆治疗。21 例(84%)患者康复,表明该疗法在该特定人群中具有潜在的治疗效果。