Limbert M, Isert D, Klesel N, Meichsner C, Seibert G, Schrinner E
Hoechst AG, Pharma Research, Frankfurt/Main, FRG.
J Antibiot (Tokyo). 1987 Dec;40(12):1762-7. doi: 10.7164/antibiotics.40.1762.
Cefotaxime (CTX) and HRE 664 (a novel penem antibiotic) possess complementary in vitro properties. Differences can be observed in their antibacterial spectra, their beta-lactamase stability and -inhibition, and their affinity to penicillin-binding proteins. These differences suggested that combinations of the cephalosporin and the penem antibiotic would be advantageous and should be studied. The fractional inhibitory concentration values of checkerboard studies confirmed that CTX and HRE 664 act synergistically against various Gram-positive and Gram-negative bacteria. Fixed combinations containing 80% CTX and 20% HRE 664 possess broader antibacterial spectra and in certain cases higher antibacterial activities than each of the components alone. The combinations had improved activity against Staphylococci including methicillin-resistant strains, beta-lactamase producing strains of Enterobacter sp. and Bacteroides fragilis. The combination as well as the single antibiotics had only limited activity against Pseudomonas aeruginosa.
头孢噻肟（CTX）和HRE 664（一种新型青霉烯类抗生素）具有互补的体外特性。在它们的抗菌谱、β-内酰胺酶稳定性及抑制作用以及对青霉素结合蛋白的亲和力方面可以观察到差异。这些差异表明头孢菌素和青霉烯类抗生素联合使用可能具有优势，值得研究。棋盘法研究的部分抑菌浓度值证实，CTX和HRE 664对多种革兰氏阳性菌和革兰氏阴性菌具有协同作用。含有80% CTX和20% HRE 664的固定组合比单独的每种成分具有更广泛的抗菌谱，在某些情况下抗菌活性更高。该组合对葡萄球菌（包括耐甲氧西林菌株）、产β-内酰胺酶的肠杆菌属菌株和脆弱拟杆菌具有更好的活性。该组合以及单一抗生素对铜绿假单胞菌的活性都有限。
