Analytical Chemistry Department, GUIA Group, I3A, EINA, University of Zaragoza, Mª de Luna 3, 50018 Zaragoza, Spain.
Analytical Chemistry Department, GUIA Group, I3A, EINA, University of Zaragoza, Mª de Luna 3, 50018 Zaragoza, Spain.
Food Chem. 2022 Jan 1;366:130592. doi: 10.1016/j.foodchem.2021.130592. Epub 2021 Jul 14.
An exhaustive migration study of eight corks, made of ethylene-vinyl acetate, was carried out to identify any non-volatile and volatile compounds using an untargeted approach. The challenge associated with the structural elucidation of unknowns was undertaken using both ultra-high-performance liquid chromatography coupled to an ion-mobility separation quadrupole-time of flight mass spectrometer and gas chromatography mass spectrometry. A total of fifty compounds were observed to migrate from the corks, and among these additives such as antioxidants (Butyl 4-hydroxybenzoate, Irganox 1010, Irganox 1075, Irgafos 168 and BHT) or lubricants (EBO and octadecanamide, N,N'-1,2-ethanediylbis-) were identified. A high proportion (84%) of the detected compounds was non-intentionally added substances (NIAS), and included several cyclic oligomers with different chain sequences. NIAS, such as 2,6-bis(1,1-dimethylethyl)-4-ethyl and 7,9-ditert-butyl-1-oxaspiro[4.5]deca-6,9-diene-2,8-dione, break-down products, including hexa-, hepta- and nonadecanamide, N,N'-1,2-ethanediylbis-, and oxidation products were also identified. One cork was found to be unsuitable for use as a food contact material.
对 8 个由乙烯-醋酸乙烯酯制成的软木塞进行了详尽的迁移研究，采用非靶向方法来鉴定任何非挥发性和挥发性化合物。使用超高效液相色谱与离子迁移分离四极杆飞行时间质谱仪和气相色谱质谱联用仪来解决未知物结构阐明的难题。共观察到 50 种化合物从软木塞中迁移出来，其中包括抗氧化剂（丁基 4-羟基苯甲酸酯、Irganox 1010、Irganox 1075、Irgafos 168 和 BHT）或润滑剂（EBO 和十八烷酰胺、N，N'-1,2-乙二基双-）等添加剂。检测到的化合物中有很大一部分（84%）是非故意添加物质（NIAS），包括具有不同链序列的几种环状低聚物。NIAS，如 2,6-双(1,1-二甲基乙基)-4-乙基和 7,9-二叔丁基-1-氧杂螺[4.5]癸-6,9-二烯-2,8-二酮，以及分解产物，包括己酰胺、庚酰胺、十九烷酰胺、N，N'-1,2-乙二基双-和氧化产物也被鉴定出来。有一个软木塞被发现不适合用作食品接触材料。
