Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Department of Obstetrics and Gynecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
J Reprod Immunol. 2021 Sep;147:103350. doi: 10.1016/j.jri.2021.103350. Epub 2021 Jul 19.
Synergistic interplay of immune endocrine interaction is prerequisite for an effective maternal fetal tolerance. Pre-term birth (PTB) may be a consequence of altered immune-endocrine crosstalk during third trimester resulting in early breakdown of this tolerance. Myeloid derived suppressor cells (MDSCs), a heterogenous population of immature immune cells are increased in pregnant women and healthy newborns, but their role in PTB still remains obscure. We now report that granulocytic MDSCs (G-MDSCs) is decreased in women delivering prematurely, suggesting their potential role in maintaining maternal fetal tolerance. Interestingly, in contrast statistically significant increase in MDSCs and monocytic MDSCs (M-MDSCs) along with positive correlation with cord serum estradiol (E2), and overexpressed ER-α in placental tissue suggested E2 mediated accumulation of M-MDSCs in PTB babies. MDSCs mediated immune suppression is accompanied with subsequent decline in total T cells and its subtypes: Th and Tc in PTB babies, which signifies their potential contribution towards the impaired immune system of PTB babies.
免疫内分泌相互作用的协同作用是实现有效母胎耐受的前提。早产 (PTB) 可能是由于妊娠晚期免疫内分泌串扰改变，导致这种耐受提前破裂的结果。髓系来源的抑制细胞 (MDSCs) 是一种异质性的未成熟免疫细胞群体，在孕妇和健康新生儿中增加，但它们在 PTB 中的作用仍不清楚。我们现在报告说，早产妇女的粒细胞 MDSCs (G-MDSCs) 减少，这表明它们在维持母胎耐受方面的潜在作用。有趣的是，与对照组相比，MDSCs 和单核细胞 MDSCs (M-MDSCs) 显著增加，与脐带血清雌二醇 (E2) 呈正相关，胎盘组织中 ER-α 过度表达提示 E2 介导的 M-MDSCs 在 PTB 婴儿中的积累。MDSCs 介导的免疫抑制伴随着 PTB 婴儿总 T 细胞及其亚型 Th 和 Tc 的随后下降，这表明它们可能对 PTB 婴儿受损的免疫系统做出贡献。
