Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Department of Clinical Laboratory, The first Hospital of Jilin University, Changchun, China.
Int Rev Immunol. 2022;41(5):534-551. doi: 10.1080/08830185.2021.1938566. Epub 2021 Jun 15.
MDSCs (myeloid-derived suppressor cells) are a population of immature and heterogeneous bone marrow cells with immunosuppressive functions, and they are mainly divided into two subgroups: granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (M-MDSCs). Immunosuppression is the main and most important function of MDSCs, and they mainly exert an inhibitory effect through endoplasmic reticulum stress and some enzymes related to inhibitors, as well as some cytokines and other factors. In addition, MDSCs also interact with other immune cells, especially NK cells, DCs and Tregs, to participate in immune regulation. A large number of MDSCs are found during normal pregnancy. Combined with their immunosuppressive effects, these results suggest that MDSCs are likely to be closely related to maternal-fetal immune tolerance. This review mainly shows the interaction of MDSCs with other immune cells and the important role of MDSCs in maternal-fetal tolerance. The current research shows that MDSCs are mainly mediated by STAT3, HLA-G, CXCR2, Arg-1 and HIF1-α in immune regulation during pregnancy. Interpreting maternal-fetal tolerance from the perspective of MDSCs provides a special perspective for research on immune regulation and maternal-fetal tolerance of MDSCs to obtain a more comprehensive understanding of immune regulation and immune tolerance.
髓源性抑制细胞（MDSCs）是一群具有免疫抑制功能的未成熟异质性骨髓细胞，主要分为两个亚群：粒细胞 MDSCs（G-MDSCs）和单核细胞 MDSCs（M-MDSCs）。免疫抑制是 MDSCs 的主要和最重要的功能，它们主要通过内质网应激和一些与抑制剂相关的酶以及一些细胞因子等因素发挥抑制作用。此外，MDSCs 还与其他免疫细胞相互作用，特别是 NK 细胞、DC 和 Tregs，参与免疫调节。在正常妊娠期间会发现大量的 MDSCs。结合它们的免疫抑制作用，这些结果表明 MDSCs 可能与母胎免疫耐受密切相关。本综述主要展示了 MDSCs 与其他免疫细胞的相互作用以及 MDSCs 在母胎耐受中的重要作用。目前的研究表明，MDSCs 主要通过 STAT3、HLA-G、CXCR2、Arg-1 和 HIF1-α 在妊娠期间的免疫调节中发挥作用。从 MDSCs 的角度来解释母胎耐受，为研究 MDSCs 对免疫调节和母胎耐受提供了一个特殊的视角，从而更全面地理解免疫调节和免疫耐受。
