Department of Ophthalmology, Northwestern Lake Forest Hospital, Lake Forest, Illinois; and.
Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Retin Cases Brief Rep. 2023 May 1;17(3):329-333. doi: 10.1097/ICB.0000000000001182. Epub 2021 Jul 16.
To describe a case of postoperative retinal toxicity following the use of mitomycin C during a routine trabeculectomy.
Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography, fundus autofluorescence, and fluorescein angiography. The study was declared exempt by the Institutional Review Board of Northwestern University. This research followed the tenets of the Declaration of Helsinki.
The patient developed profound vision loss and retinal damage during the postoperative course. Posterior segment findings include loss of vascular perfusion, diffuse loss of the outer, then inner, retinal layers, and subsequent total retinal detachment.
Although mitomycin C is commonly used in glaucoma filtering surgeries, reports of postoperative posterior segment toxicity are rare. The etiology of postoperative toxicity in this case is probable inadvertent intraocular injection of mitomycin C.
描述一例在常规小梁切开术中使用丝裂霉素 C 后发生的术后视网膜毒性。
对 1 例患者进行了全面的眼科检查和多种模式成像，包括眼底彩色照片、光学相干断层扫描、眼底自发荧光和荧光血管造影。该研究已被西北大学机构审查委员会豁免。本研究遵循《赫尔辛基宣言》的原则。
患者在术后过程中出现严重的视力丧失和视网膜损伤。后节发现包括血管灌注丧失、外层视网膜广泛丢失，然后是内层视网膜丢失，随后发生全视网膜脱离。
虽然丝裂霉素 C 常用于青光眼滤过性手术，但术后后节毒性的报道很少。本例术后毒性的病因可能是意外眼内注射丝裂霉素 C。
