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丝裂霉素C脉络膜上腔迁移继发的视网膜毒性

Retinal Toxicity Secondary to Suprachoroidal Migration of Mitomycin-C.

作者信息

Dirani Karim, Alfaro Cesar, Ridha Al-Timimi Faisal, Juzych Daniel, Yoganathan Pradeepa

机构信息

Kresge Eye Institute, Detroit, MI, USA.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

出版信息

J Vitreoretin Dis. 2024 Aug 31;8(6):744-748. doi: 10.1177/24741264241269533. eCollection 2024 Nov-Dec.

DOI:10.1177/24741264241269533
PMID:39554626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11561915/
Abstract

To report a case of suprachoroidal migration of mitomycin-C (MMC) with ensuing retinal toxicity after trabeculectomy. A case report of retinal toxicity is described with multimodal imaging. A patient developed occlusion of the retinal and choroidal vasculature in a segmental fashion that could be explained by suprachoroidal diffusion. Fundus autofluorescence showed a stippled pattern over an area of hypofluorescence in the superonasal quadrant, and a late fluorescein angiogram image showed staining of the superonasal quadrant with dependent leakage toward the optic nerve and macula. MMC is commonly used in glaucoma-filtering surgical procedures, and few cases of postoperative posterior segment toxicity have been reported. To our knowledge, we are the first to describe suprachoroidal migration of MMC with subsequent retinal toxicity.

摘要

报告一例小梁切除术后丝裂霉素C（MMC）脉络膜上腔迁移并继发视网膜毒性的病例。本文通过多模态成像描述了一例视网膜毒性的病例报告。一名患者出现视网膜和脉络膜血管节段性闭塞，这可以用脉络膜上腔扩散来解释。眼底自发荧光显示鼻上象限低荧光区域呈点状图案，荧光素血管造影晚期图像显示鼻上象限染色，并向视神经和黄斑区出现依赖性渗漏。MMC常用于青光眼滤过性手术，术后眼后段毒性的病例报道较少。据我们所知，我们是首个描述MMC脉络膜上腔迁移并继发视网膜毒性的。

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本文引用的文献

1
RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY.在小梁切除术中疑似意外眼内注射丝裂霉素 C 后的视网膜毒性。
Retin Cases Brief Rep. 2023 May 1;17(3):329-333. doi: 10.1097/ICB.0000000000001182. Epub 2021 Jul 16.
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Consequences of inadvertent intravitreal Mitomycin C injection.玻璃体内意外注射丝裂霉素C的后果。
Int J Retina Vitreous. 2018 Feb 12;4:7. doi: 10.1186/s40942-018-0110-6. eCollection 2018.
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A review of the efficacy of mitomycin C in glaucoma filtration surgery.丝裂霉素C在青光眼滤过手术中的疗效综述。
Clin Ophthalmol. 2015 Oct 20;9:1945-51. doi: 10.2147/OPTH.S80111. eCollection 2015.
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Mitomycin: clinical applications in ophthalmic practice.丝裂霉素：眼科临床应用
Drugs. 2006;66(3):321-40. doi: 10.2165/00003495-200666030-00005.
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Ocular toxicity of mitomycin-C.丝裂霉素C的眼毒性。
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