Department of Physiology, Laboratory for Reproductive Biology and Developmental Programming, Edo University Iyamho, Iyamho, Nigeria.
Discipline of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
J Basic Clin Physiol Pharmacol. 2021 Jul 22;33(1):27-44. doi: 10.1515/jbcpp-2020-0533.
Studies have shown that severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is a highly infectious disease, with global deaths rising to about 360,438 as of 28 May 2020. Different countries have used various approaches such as lockdown, social distancing, maintenance of personal hygiene, and increased establishment of testing and isolation centers to manage the pandemic. Poor biomedical waste (BMW) management, treatment, and disposal techniques, especially SARS-CoV-2 infected BMW, may threaten the environmental and public health in most developing countries and, by extension, impact the economic status of individuals and the nation at large. This may increase the potential for the transmission of air/blood body fluid-borne pathogens, increase the growth of microorganisms, risk of mutagenesis, and upsurge of more virulent strain. In contrast, uncontrolled substandard burning could increase the potential spread of nosocomial infection and environmental exposure to toxic organic compounds, heavy metals, radioactive, and genotoxic bio-aerosols which might be present in the gaseous, liquid, and solid by-products. The paucity of understanding of pathophysiology and management of the SARS-CoV-2 pandemic has also necessitated the need to put in place appropriate disposal techniques to cater for the sudden increase in the global demand for personal protective equipment (PPE) and pharmaceutical drugs to manage the pandemic and to reduce the risk of preventable infection by the waste. Therefore, there is a need for adequate sensitization, awareness, and environmental monitoring of the impacts of improper handling of SARS-CoV-2 infected BMWs. Hence, this review aimed to address the issues relating to the improper management of increased SARS-CoV-2 infected BMW in low middle-income countries (LMICs).
研究表明,严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2)是一种高度传染性疾病,截至 2020 年 5 月 28 日,全球死亡人数约为 360438 人。不同国家采用了封锁、社交距离、保持个人卫生以及增加检测和隔离中心等各种方法来管理大流行。贫穷国家的生物医学废物(BMW)管理不善、处理和处置技术,特别是 SARS-CoV-2 感染的 BMW,可能会威胁到大多数发展中国家的环境和公共卫生,进而影响个人和整个国家的经济状况。这可能会增加空气/血液体液传播病原体、微生物生长、致突变风险以及更毒力菌株增加的潜力。相比之下,不受控制的不合标准的燃烧可能会增加医院感染和环境暴露于有毒有机化合物、重金属、放射性和遗传毒性生物气溶胶的潜在风险,这些物质可能存在于气体、液体和固体副产物中。对 SARS-CoV-2 大流行的病理生理学和管理的理解不足,也需要采取适当的处置技术,以满足全球对个人防护设备(PPE)和药物的需求的突然增加,以管理大流行并降低废物引起的可预防感染的风险。因此,需要充分认识到 SARS-CoV-2 感染的 BMW 处理不当所带来的影响,并进行宣传、提高认识和环境监测。因此,本综述旨在解决与中低收入国家(LMICs)中 SARS-CoV-2 感染的 BMW 处理不当相关的问题。