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长链非编码RNA PSMA3-AS1通过调控miR-411-3p/HOXA10通路促进胶质瘤进展。

Long non-coding RNA PSMA3-AS1 promotes glioma progression through modulating the miR-411-3p/HOXA10 pathway.

作者信息

Huang Tianzao, Chen Yingxian, Zeng Yile, Xu Chaoyang, Huang Jinzhong, Hu Weipeng, Chen Xiangrong, Fu Huangde

机构信息

Department of Neurosurgery, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, 362000, Fujian, China.

Department of Neurosurgery, The Jinjiang Municipal Hospital, Quanzhou, Fujian, China.

出版信息

BMC Cancer. 2021 Jul 22;21(1):844. doi: 10.1186/s12885-021-08465-5.

DOI:10.1186/s12885-021-08465-5
PMID:34294084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8296684/
Abstract

BACKGROUND

Glioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in numerous tumors or diseases including glioma. Proteasome 20S subunit alpha 3 antisense RNA 1 (PSMA3-AS1), as a member of lncRNAs, has been disclosed to play a tumor-promoting role in cancer progression. However, the role of PSMA3-AS1 in glioma remains unknown. Therefore, we concentrated on researching the regulatory mechanism of PSMA3-AS1 in glioma.

METHODS

PSMA3-AS1 expression was detected using RT-qPCR. Functional assays were performed to measure the effects of PSMA3-AS1 on glioma progression. After that, ENCORI ( http://starbase.sysu.edu.cn/ ) database was used to predict potential genes that could bind to PSMA3-AS1, and miR-411-3p was chosen for further studies. The interaction among PSMA3-AS1, miR-411-3p and homeobox A10 (HOXA10) were confirmed through mechanism assays.

RESULTS

PSMA3-AS1 was verified to be up-regulated in glioma cells and promote glioma progression. Furthermore, PSMA3-AS1 could act as a competitive endogenous RNA (ceRNA) for miR-411-3p to regulate HOXA10 and thus affecting glioma progression.

CONCLUSION

PSMA3-AS1 stimulated glioma progression via the miR-411-3p/HOXA10 pathway, which might offer a novel insight for the therapy and treatment of glioma.

摘要

背景

胶质瘤是一种常见的脑肿瘤类型，根据形态学和分子特征可分为低级别和高级别。越来越多的证据表明，长链非编码RNA（lncRNA）在包括胶质瘤在内的众多肿瘤或疾病中发挥着关键作用。蛋白酶体20S亚基α3反义RNA 1（PSMA3-AS1）作为lncRNA的一员，已被揭示在癌症进展中发挥促肿瘤作用。然而，PSMA3-AS1在胶质瘤中的作用尚不清楚。因此，我们专注于研究PSMA3-AS1在胶质瘤中的调控机制。

方法

采用RT-qPCR检测PSMA3-AS1的表达。进行功能实验以测定PSMA3-AS1对胶质瘤进展的影响。之后，利用ENCORI（http://starbase.sysu.edu.cn/）数据库预测可能与PSMA3-AS1结合的潜在基因，并选择miR-411-3p进行进一步研究。通过机制实验证实了PSMA3-AS1、miR-411-3p和同源框A10（HOXA10）之间的相互作用。

结果

证实PSMA3-AS1在胶质瘤细胞中上调并促进胶质瘤进展。此外，PSMA3-AS1可作为miR-411-3p的竞争性内源性RNA（ceRNA）来调节HOXA10，从而影响胶质瘤进展。

结论

PSMA3-AS1通过miR-411-3p/HOXA10途径刺激胶质瘤进展，这可能为胶质瘤的治疗提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/f802fbecad86/12885_2021_8465_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/232d0b61e99f/12885_2021_8465_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/827f7f0d36cc/12885_2021_8465_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/c61d8e77ada5/12885_2021_8465_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/630e49af7a1c/12885_2021_8465_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/f802fbecad86/12885_2021_8465_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/232d0b61e99f/12885_2021_8465_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/827f7f0d36cc/12885_2021_8465_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/c61d8e77ada5/12885_2021_8465_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/630e49af7a1c/12885_2021_8465_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f541/8296684/f802fbecad86/12885_2021_8465_Fig5_HTML.jpg

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2
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3
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Curr Pharm Des. 2025;31(21):1683-1695. doi: 10.2174/0113816128350406241223053744.
4
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6
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