Eldakhakhny Basmah, Sutaih Abdulaziz M, Siddiqui Moaaz A, Aqeeli Yamin M, Awan Akram Z, Alsayegh Mohammad Y, Elsamanoudy Salma A, Elsamanoudy Ayman
Clinical Biochemistry Department, Faculty of Medicine, King Abdulaziz University, Jeddah, 21465, Saudi Arabia.
Food, Nutrition, and Lifestyle Research Unit, King Fahd for Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia.
Noncoding RNA Res. 2024 Jul 1;9(4):1315-1323. doi: 10.1016/j.ncrna.2024.06.015. eCollection 2024 Dec.
This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular RNAs (circRNAs), long noncoding RNAs (lncRNAs), and microRNAs (miRNAs). We discuss how ncRNAs affect gene expression in cancerous cells, the spread of cancer, and metastasis. The article illustrates the complex pathways through which ncRNAs can affect oncogenesis, tumor suppression, and therapeutic resistance. It also assesses the potential clinical uses of non-coding RNAs (ncRNAs), including their utility in cancer diagnosis, and prognosis. Besides, their potential for personalized cancer therapy is documented. Finally, it is concluded that understanding the role of ncRNA is of clinical importance regarding carcinogenesis, cancer diagnosis, and personalized therapy.
这篇综述文章研究了癌症生物学中非编码RNA（ncRNAs）这一复杂领域，重点关注它们作为生物标志物和治疗靶点的潜在用途。非编码RNA包括环状RNA（circRNAs）、长链非编码RNA（lncRNAs）和微小RNA（miRNAs）。我们讨论了非编码RNA如何影响癌细胞中的基因表达、癌症的扩散和转移。本文阐述了非编码RNA影响肿瘤发生、肿瘤抑制和治疗耐药性的复杂途径。文章还评估了非编码RNA（ncRNAs）的潜在临床用途，包括它们在癌症诊断和预后方面的效用。此外，还记录了它们在个性化癌症治疗中的潜力。最后得出结论，了解非编码RNA在致癌作用、癌症诊断和个性化治疗方面的作用具有临床重要性。
