College of Light Industry and Food Engineering, Guangxi University, Guangxi, Nanning 530004, China.
College of Light Industry and Food Engineering, Guangxi University, Guangxi, Nanning 530004, China; Collaborative Innovation Center for Guangxi Sugarcane Industry, Guangxi University, Nanning 530004, China; Engineering Research Center for Sugar Industry and Comprehensive Utilization, Ministry of Education, Nanning 530004, China.
Carbohydr Polym. 2021 Oct 1;269:118248. doi: 10.1016/j.carbpol.2021.118248. Epub 2021 May 26.
The differences in the source and structure of xylans make them have various biological activities. However, due to their inherent structural limitations, the various biological activities of xylans are far lower than those of commercial drugs. Currently, several types of molecular modification methods have been developed to address these limitations, and many derivatives with specific biological activity have been obtained. Further research on structural characteristics, structure-activity relationship and mechanism of action is of great significance for the development of xylan derivatives. Therefore, the major molecular modification methods of xylans are introduced in this paper, and the primary structure and conformation characteristics of xylans and their derivatives are summarized. In addition, the biological activity and structure-activity relationship of the modified xylans are also discussed.
木聚糖在来源和结构上的差异使其具有多种生物活性。然而，由于其固有的结构局限性，木聚糖的各种生物活性远低于商业药物。目前，已经开发出几种类型的分子修饰方法来解决这些局限性，并获得了许多具有特定生物活性的衍生物。进一步研究木聚糖衍生物的结构特征、构效关系和作用机制具有重要意义。因此，本文介绍了木聚糖的主要分子修饰方法，并总结了木聚糖及其衍生物的一级结构和构象特征。此外，还讨论了修饰木聚糖的生物活性和构效关系。
