College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, PR China; State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, PR China; Yangzhou Rixing Bio-Tech Co., Ltd., Yangzhou 225601, PR China.
College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, PR China.
Carbohydr Polym. 2021 Oct 1;269:118320. doi: 10.1016/j.carbpol.2021.118320. Epub 2021 Jun 9.
Hyaluronic acid (HA) is a naturally formed acidic mucopolysaccharide, with excellent moisturising properties and used widely in the medicine, cosmetics, and food industries. The industrial production of specific molecular weight HA has become imperative. Different biological activities and physiological functions of HA mainly depend on the degree of polymerisation. This article reviews the research status and development prospects of the green biosynthesis and molecular weight regulation of HA. There is an application-based prerequisite of specific molecular weight of HA that could be regulated either during the fermentation process or via a controlled HA degradation process. This work provides an important theoretical basis for the downstream efficient production of diversified HA, which will further accelerate the research applications of HA and provide a good scientific basis and method reference for the study of the molecular weight regulation of similar biopolymers.
透明质酸（HA）是一种天然形成的酸性黏多糖，具有极佳的保湿性能，广泛应用于医药、化妆品和食品工业。特定分子量 HA 的工业生产已变得势在必行。HA 的不同生物学活性和生理功能主要取决于聚合度。本文综述了 HA 的绿色生物合成和分子量调控的研究现状和发展前景。HA 的特定分子量具有应用基础，可在发酵过程中或通过控制 HA 降解过程进行调节。这项工作为下游高效生产多样化的 HA 提供了重要的理论基础，将进一步加速 HA 的研究应用，并为类似生物聚合物分子量调控的研究提供良好的科学基础和方法参考。
