Bustamante-Montes Lilia Patricia, Borja-Aburto Víctor Hugo, Hernández-Valero María, García-Fábila María Magdalena, Borja-Bustamante Patricia, González-Álvarez Rafael
Universidad Autónoma de Guadalajara, Decanato de Ciencias de la Salud, Guadalajara, Jalisco, Mexico.
Instituto Mexicano del Seguro Social (IMSS), Coordinacion de Vigilancia Epidemiologica, Ciudad de Mexico, Mexico.
Toxicol Rep. 2021 Jul 8;8:1399-1403. doi: 10.1016/j.toxrep.2021.07.005. eCollection 2021.
Phthalates affect development of male reproductive system acting as an antiandrogenic agents. We sought to explore if perinatal exposure to phthalates could alter male hormone levels in humans during the first months of life. A cohort of 83 pregnant women and their male infants were studied. Five phthalate metabolites were measured in the mother's urine during the first, second, and third trimesters of pregnancy and during the first, third, and sixth months of life in the infants. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone and inhibin B were analyzed. Association between phthalate exposure and hormone variation was assessed using regression models for longitudinal data. Mono-butyl phthalate reduced FSH concentration (ß = -0.0012 international units [IU]/L, < 0.01), mono-ethylhexyl phthalate reduced inhibin B (ß = -0.0094 pg/mL, = 0.02), monoethyl phthalate reduced testosterone (ß = -0.0071 ng/L, = 0.07), mono-ocytl phthalate reduced LH (ß = -0.0041 IU/L, = 0.13). No effects were observed for exposure to mono-methyl phthalate. Our results are consistent with the findings in animal and human studies. Special precaution should be taken when measuring phthalate exposure in susceptible populations such as pregnant women and infants.
邻苯二甲酸盐作为抗雄激素剂会影响男性生殖系统的发育。我们试图探究围产期接触邻苯二甲酸盐是否会在人类生命的最初几个月改变男性激素水平。对83名孕妇及其男婴组成的队列进行了研究。在孕妇怀孕的第一、第二和第三个孕期以及婴儿出生后的第一、第三和第六个月，检测其尿液中的五种邻苯二甲酸酯代谢物。分析了促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮和抑制素B。使用纵向数据回归模型评估邻苯二甲酸盐暴露与激素变化之间的关联。邻苯二甲酸单丁酯降低了FSH浓度（β=-0.0012国际单位[IU]/L，P<0.01），邻苯二甲酸单乙基己酯降低了抑制素B（β=-0.0094 pg/mL，P=0.02），邻苯二甲酸单乙酯降低了睾酮（β=-0.0071 ng/L，P=0.07），邻苯二甲酸单辛酯降低了LH（β=-0.0041 IU/L，P=0.13）。未观察到接触邻苯二甲酸单甲酯有任何影响。我们的结果与动物和人体研究的结果一致。在测量孕妇和婴儿等易感人群的邻苯二甲酸盐暴露时应特别谨慎。
