Department of Pathology, 'Grigore T. Popa' University of Medicine and Pharmacy, Iași 700115, Romania.
Department of Histology, 'Grigore T. Popa' University of Medicine and Pharmacy, Iași 700115, Romania.
Mol Med Rep. 2021 Sep;24(3). doi: 10.3892/mmr.2021.12302. Epub 2021 Jul 23.
Ghrelin, an orexigenic hormone, is a peptide that binds to the growth hormone secretagogue receptor; it is secreted mainly by enteroendocrine cells in the oxyntic glands of the stomach. Ghrelin serves a role in both local and systemic physiological processes, and is implicated in various pathologies, including neoplasia, with tissue expression in several types of malignancies in both and studies. However, the precise implications of the ghrelin axis in metastasis, invasion and cancer progression regulation has yet to be established. In the case of gastrointestinal (GI) tract malignancies, ghrelin has shown potential to become a prognostic factor or even a therapeutic target, although data in the literature are inconsistent and unsystematic, with reports untailored to a specific histological subtype of cancer or a particular localization. The evaluation of immunohistochemical expression shows a limited outlook owing to the low number of cases analyzed, and analyses have conflicting data regarding differences in ghrelin serum levels in patients with cancer. The aim of this review was to examine the relationship between ghrelin and GI tract malignancies to demonstrate the inconsistencies in current results and to highlight its clinical significance in the outcome of these patients.
胃饥饿素是一种促食欲激素，是一种与生长激素促分泌素受体结合的肽，主要由胃幽门腺的肠内分泌细胞分泌。胃饥饿素在局部和全身生理过程中都发挥作用，并与多种病理学相关，包括肿瘤，在 和 研究中，多种恶性肿瘤组织中均有胃饥饿素表达。然而，胃饥饿素轴在转移、侵袭和癌症进展调节中的确切作用尚未确定。在胃肠道（GI）道恶性肿瘤中，胃饥饿素有可能成为预后因素，甚至治疗靶点，尽管文献中的数据不一致且不系统，报告也没有针对癌症的特定组织学亚型或特定定位进行调整。免疫组织化学表达的评估由于分析的病例数量有限，因此前景有限，并且 分析关于癌症患者血清胃饥饿素水平差异的数据存在矛盾。本综述的目的是检查胃饥饿素与胃肠道恶性肿瘤之间的关系，以证明当前结果的不一致性，并强调其在这些患者结局中的临床意义。
